Transcriptional regulation of GLUT4 gene expression

Ann Louise Olson, Jeffrey E. Pessin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The in-vivo expression of the muscle/adipose-specific GLUT4 gene is down regulated under conditions of relative insulin-deficiency such as fasting and streptozotocin (STZ)-induced diabetes. These alterations in GLUT4 transcription occur in a tissue-specific manner with a significantly greater reduction in cardiac and adipose tissue compared to skeletal muscle. To identify the cis-DNA elements responsible for the complex pattern of tissue-specific and nutritional/metabolic regulation, transgenic mice have successfully been used to examine the expression of the human GLUT4 gene. These data have demonstrated the presence of at least two functional regions required for the appropriate tissue-specific and nutritional/metabolic regulation of GLUT4 gene expression.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume7
Issue number2
DOIs
StatePublished - Apr 1996
Externally publishedYes

Fingerprint

Gene Expression Regulation
Experimental Diabetes Mellitus
Transgenic Mice
Genes
Adipose Tissue
Fasting
Skeletal Muscle
Insulin
Muscles
DNA

Keywords

  • Diabetes
  • Gene regulation
  • GLUT4
  • Transcription

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Transcriptional regulation of GLUT4 gene expression. / Olson, Ann Louise; Pessin, Jeffrey E.

In: Seminars in Cell and Developmental Biology, Vol. 7, No. 2, 04.1996, p. 287-293.

Research output: Contribution to journalArticle

@article{0956acf95a7942608564783fa34b1833,
title = "Transcriptional regulation of GLUT4 gene expression",
abstract = "The in-vivo expression of the muscle/adipose-specific GLUT4 gene is down regulated under conditions of relative insulin-deficiency such as fasting and streptozotocin (STZ)-induced diabetes. These alterations in GLUT4 transcription occur in a tissue-specific manner with a significantly greater reduction in cardiac and adipose tissue compared to skeletal muscle. To identify the cis-DNA elements responsible for the complex pattern of tissue-specific and nutritional/metabolic regulation, transgenic mice have successfully been used to examine the expression of the human GLUT4 gene. These data have demonstrated the presence of at least two functional regions required for the appropriate tissue-specific and nutritional/metabolic regulation of GLUT4 gene expression.",
keywords = "Diabetes, Gene regulation, GLUT4, Transcription",
author = "Olson, {Ann Louise} and Pessin, {Jeffrey E.}",
year = "1996",
month = "4",
doi = "10.1006/scdb.1996.0037",
language = "English (US)",
volume = "7",
pages = "287--293",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Transcriptional regulation of GLUT4 gene expression

AU - Olson, Ann Louise

AU - Pessin, Jeffrey E.

PY - 1996/4

Y1 - 1996/4

N2 - The in-vivo expression of the muscle/adipose-specific GLUT4 gene is down regulated under conditions of relative insulin-deficiency such as fasting and streptozotocin (STZ)-induced diabetes. These alterations in GLUT4 transcription occur in a tissue-specific manner with a significantly greater reduction in cardiac and adipose tissue compared to skeletal muscle. To identify the cis-DNA elements responsible for the complex pattern of tissue-specific and nutritional/metabolic regulation, transgenic mice have successfully been used to examine the expression of the human GLUT4 gene. These data have demonstrated the presence of at least two functional regions required for the appropriate tissue-specific and nutritional/metabolic regulation of GLUT4 gene expression.

AB - The in-vivo expression of the muscle/adipose-specific GLUT4 gene is down regulated under conditions of relative insulin-deficiency such as fasting and streptozotocin (STZ)-induced diabetes. These alterations in GLUT4 transcription occur in a tissue-specific manner with a significantly greater reduction in cardiac and adipose tissue compared to skeletal muscle. To identify the cis-DNA elements responsible for the complex pattern of tissue-specific and nutritional/metabolic regulation, transgenic mice have successfully been used to examine the expression of the human GLUT4 gene. These data have demonstrated the presence of at least two functional regions required for the appropriate tissue-specific and nutritional/metabolic regulation of GLUT4 gene expression.

KW - Diabetes

KW - Gene regulation

KW - GLUT4

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=0000268923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000268923&partnerID=8YFLogxK

U2 - 10.1006/scdb.1996.0037

DO - 10.1006/scdb.1996.0037

M3 - Article

VL - 7

SP - 287

EP - 293

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 2

ER -