Reglarea şi coordonarea transcrierii unor gene de semnalizare intercelulara în creierul şi inima de şoarece deficitar de conexina 43.

Translated title of the contribution: Transcription regulation and coordination of some cell signaling genes in brain and heart of connexin 43 null mouse

D. A. Iacobaş, Marcia Urban, Sanda Iacobaş, D. C. Spray

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We performed a cDNA microarray study of the transcription regulation and coordination of four gene families whose products are involved in cell-cell and cell-matrix interaction (ADAM, integrin, MMP, TNF) within brain and hearts of wildtype (WT) and connexin43 null (KO) neonatal C57Bl/6j mice. The study revealed that both WT brain and heart exhibit significant correlations among the transcriptions of cell-signaling genes and that depletion of Cx43 regulates both their expression and coordination. Adam8 was identified as the command gene of the group in WT and Mmp2 in KO, while Tnsf6 plays the dominant role in both WT and KO heart. Our results suggest that the functional coordination of cell-signaling proteins may be related to the expression coordination of the corresponding genes presumably to ensure the efficiency of the functional pathways and that intercellular communication modulates cell-cell and cell-matrix interaction.

Translated title of the contributionTranscription regulation and coordination of some cell signaling genes in brain and heart of connexin 43 null mouse
Original languageRomanian
Pages (from-to)534-539
Number of pages6
JournalRevista medico-chirurgicala a Societaţii de Medici ş̧i Naturaliş̧ti din Iaş̧i
Volume107
Issue number3
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)

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