Toxicology of alkylmercury compounds

Michael Aschner, Natalia Onishchenko, Sandra Ceccatelli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.

Original languageEnglish (US)
Title of host publicationOrganometallics in Environment and Toxicology
Publisherde Gruyter
Pages403-434
Number of pages32
Volume7
ISBN (Electronic)9783110436600
ISBN (Print)9783110442809
StatePublished - Jul 24 2015
Externally publishedYes

Keywords

  • Ethylmercury
  • Mechanisms
  • Mercury
  • Methylmercury
  • Neurodegenerative diseases
  • Neurodevelopment
  • Neurotoxicity

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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