Toxicology of alkylmercury compounds.

Michael Aschner, Natalia Onishchenko, Sandra Ceccatelli

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.

Original languageEnglish (US)
Pages (from-to)403-434
Number of pages32
JournalMetal ions in life sciences
Volume7
StatePublished - 2010
Externally publishedYes

Fingerprint

Alkylmercury Compounds
Mercury Compounds
Food Chain
Neurotoxins
Sulfhydryl Compounds
Biochemistry
Toxicology
Central Nervous System
Wounds and Injuries
Brain
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aschner, M., Onishchenko, N., & Ceccatelli, S. (2010). Toxicology of alkylmercury compounds. Metal ions in life sciences, 7, 403-434.

Toxicology of alkylmercury compounds. / Aschner, Michael; Onishchenko, Natalia; Ceccatelli, Sandra.

In: Metal ions in life sciences, Vol. 7, 2010, p. 403-434.

Research output: Contribution to journalArticle

Aschner, M, Onishchenko, N & Ceccatelli, S 2010, 'Toxicology of alkylmercury compounds.', Metal ions in life sciences, vol. 7, pp. 403-434.
Aschner M, Onishchenko N, Ceccatelli S. Toxicology of alkylmercury compounds. Metal ions in life sciences. 2010;7:403-434.
Aschner, Michael ; Onishchenko, Natalia ; Ceccatelli, Sandra. / Toxicology of alkylmercury compounds. In: Metal ions in life sciences. 2010 ; Vol. 7. pp. 403-434.
@article{ba949b83cbde4e618f31357b861dd925,
title = "Toxicology of alkylmercury compounds.",
abstract = "Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.",
author = "Michael Aschner and Natalia Onishchenko and Sandra Ceccatelli",
year = "2010",
language = "English (US)",
volume = "7",
pages = "403--434",
journal = "Metal ions in life sciences",
issn = "1559-0836",
publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Toxicology of alkylmercury compounds.

AU - Aschner, Michael

AU - Onishchenko, Natalia

AU - Ceccatelli, Sandra

PY - 2010

Y1 - 2010

N2 - Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.

AB - Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.

UR - http://www.scopus.com/inward/record.url?scp=79952277223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952277223&partnerID=8YFLogxK

M3 - Article

C2 - 20877814

AN - SCOPUS:79952277223

VL - 7

SP - 403

EP - 434

JO - Metal ions in life sciences

JF - Metal ions in life sciences

SN - 1559-0836

ER -