Toxicology of alkylmercury compounds.

Michael Aschner, Natalia Onishchenko, Sandra Ceccatelli

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Methylmercury is a global pollutant and potent neurotoxin whose abundance in the food chain mandates additional studies on the consequences and mechanisms of its toxicity to the central nervous system. Formulation of our new hypotheses was predicated on our appreciation for (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, and (b) the essential role of thiols in protein biochemistry. The present chapter addresses pathways to human exposure of various mercury compounds, highlighting their neurotoxicity and potential involvement in neurotoxic injury and neurodegenerative changes, both in the developing and senescent brain. Mechanisms that trigger these effects are discussed in detail.

Original languageEnglish (US)
Pages (from-to)403-434
Number of pages32
JournalMetal Ions in Life Sciences
Volume7
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Aschner, M., Onishchenko, N., & Ceccatelli, S. (2010). Toxicology of alkylmercury compounds. Metal Ions in Life Sciences, 7, 403-434.