TY - JOUR
T1 - Toxicity of three types of arsenolipids
T2 - Species-specific effects in: Caenorhabditis elegans
AU - Bornhorst, Julia
AU - Ebert, Franziska
AU - Meyer, Sören
AU - Ziemann, Vanessa
AU - Xiong, Chan
AU - Guttenberger, Nikolaus
AU - Raab, Andrea
AU - Baesler, Jessica
AU - Aschner, Michael
AU - Feldmann, Jörg
AU - Francesconi, Kevin
AU - Raber, Georg
AU - Schwerdtle, Tanja
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2020/5
Y1 - 2020/5
N2 - Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.
AB - Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.
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U2 - 10.1039/d0mt00039f
DO - 10.1039/d0mt00039f
M3 - Article
C2 - 32232250
AN - SCOPUS:85085531578
SN - 1756-5901
VL - 12
SP - 794
EP - 798
JO - Metallomics
JF - Metallomics
IS - 5
ER -