TY - JOUR
T1 - Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
AU - Skalny, Anatoly V.
AU - Lima, Thania Rios Rossi
AU - Ke, Tao
AU - Zhou, Ji Chang
AU - Bornhorst, Julia
AU - Alekseenko, Svetlana I.
AU - Aaseth, Jan
AU - Anesti, Ourania
AU - Sarigiannis, Dimosthenis A.
AU - Tsatsakis, Aristides
AU - Aschner, Michael
AU - Tinkov, Alexey A.
N1 - Funding Information:
The study was performed with the support of the Russian Ministry of Science and Higher Education , Project № 0856-2020-00082 . MA was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS) R01ES07331 and R01ES105633 . We further thank the German Research Foundation (DFG) , DFG Research Unit FOR 2558 .
Funding Information:
The study was performed with the support of the Russian Ministry of Science and Higher Education, Project ? 0856-2020-00082. MA was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS) R01ES07331 and R01ES105633. We further thank the German Research Foundation (DFG), DFG Research Unit FOR 2558.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/12
Y1 - 2020/12
N2 - Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.
AB - Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.
KW - Arsenic
KW - Cadmium
KW - Immunity
KW - Lead
KW - Mercury
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U2 - 10.1016/j.fct.2020.111809
DO - 10.1016/j.fct.2020.111809
M3 - Article
C2 - 33069759
AN - SCOPUS:85093941383
VL - 146
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
M1 - 111809
ER -