Total plasma homocysteine values among elderly subjects: Findings from the Maracaibo Aging Study

Aldrin E. Molero, Carmen C. Altimari, Dariana A. Duran, Esperanza Garcia, Gloria Pino-Ramirez, Gladys E. Maestre

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objectives: The present study generated baseline data for total homocysteine (tHcy) in elderly Caribbeans of Hispanic ancestry, residing in Venezuela, their country of origin. Design and methods: 2106 participants in the Maracaibo Aging Study (MAS), older than 55 years, underwent standardized clinical and laboratory assessments, including measurement of plasma tHcy levels, folate, and vitamin B12 in fasting samples. Results: tHcy concentration in the healthy, normative group ranged from 4.1 to 31.8 μmol/L, with a median of 11.5 ± 4.7 μmol/L. tHcy level increased with age, was significantly higher in men than in women, and exhibited inverse correlations with folate and vitamin B12. Conclusions: tHcy levels of the MAS participants were generally higher than levels previously reported for community-dwelling elderly populations from other countries. The normative centile curves for tHcy can be used in disease risk analysis for this population, and possibly for other Hispanic populations residing in the Caribbean.

Original languageEnglish (US)
Pages (from-to)1007-1015
Number of pages9
JournalClinical Biochemistry
Volume39
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • Aging
  • Caribbean
  • Elderly
  • Homocysteine
  • Risk factor

ASJC Scopus subject areas

  • Clinical Biochemistry

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