To be or not to be B7

Xingxing Zang, James P. Allison

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The activation of lymphocytes and development of adaptive immune responses is initiated by the engagement of TCRs by antigenic peptide-MHC complexes and shaped at the clonal level by both positive and negative costimulatory signals. The B7 family members are involved at several stages in this process. In this issue of the JCI, Vogt et al. show that the B7 family-related protein V-set and Ig domain-containing 4 (VSIG4) can act as an inhibitor of T cell activation (see the related article beginning on page 2817). Intriguingly, the same molecule was recently independently identified as a complement receptor of the Ig superfamily (CRIg) and was convincingly demonstrated to be a receptor for complement component 3 fragments. These findings raise interesting questions regarding the physiological roles and mechanisms of action of this molecule. Identification of dual functions of this molecule provides an additional level of complexity in T cell costimulation.

Original languageEnglish (US)
Pages (from-to)2590-2593
Number of pages4
JournalJournal of Clinical Investigation
Issue number10
StatePublished - Oct 2 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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