TY - JOUR
T1 - TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core
AU - Valle-Casuso, Jose Carlos
AU - Di Nunzio, Francesca
AU - Yang, Yang
AU - Reszka, Natalia
AU - Lienlaf, Maritza
AU - Arhel, Nathalie
AU - Perez, Patricio
AU - Brass, Abraham L.
AU - Diaz-Griffero, Felipe
PY - 2012/5
Y1 - 2012/5
N2 - TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import.
AB - TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import.
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U2 - 10.1128/JVI.00451-12
DO - 10.1128/JVI.00451-12
M3 - Article
C2 - 22398280
AN - SCOPUS:84861323711
SN - 0022-538X
VL - 86
SP - 5931
EP - 5936
JO - Journal of virology
JF - Journal of virology
IS - 10
ER -
