Thymic Hypoplasia Associated With Isotretinoin Embryopathy

Morris Cohen; Arye Rubinstein; John K. Li; Gerald Nathenson

doi:10.1001/archpedi.1987.04460030041020

Thymic Hypoplasia Associated With Isotretinoin Embryopathy

Morris Cohen, Arye Rubinstein, John K. Li, Gerald Nathenson

Pediatrics

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

Original language	English (US)
Pages (from-to)	263-266
Number of pages	4
Journal	American Journal of Diseases of Children
Volume	141
Issue number	3
DOIs	https://doi.org/10.1001/archpedi.1987.04460030041020
State	Published - Mar 1987

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1001/archpedi.1987.04460030041020

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title = "Thymic Hypoplasia Associated With Isotretinoin Embryopathy",

abstract = "A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.",

author = "Morris Cohen and Arye Rubinstein and Li, {John K.} and Gerald Nathenson",

year = "1987",

month = mar,

doi = "10.1001/archpedi.1987.04460030041020",

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AU - Cohen, Morris

AU - Rubinstein, Arye

AU - Li, John K.

AU - Nathenson, Gerald

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N2 - A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

AB - A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

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AN - SCOPUS:0023124585

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JO - American Journal of Diseases of Children

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ER -

Thymic Hypoplasia Associated With Isotretinoin Embryopathy

Abstract

ASJC Scopus subject areas

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