Thymic Hypoplasia Associated With Isotretinoin Embryopathy

Morris Cohen, Arye Rubinstein, John K. Li, Gerald Nathenson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume141
Issue number3
DOIs
StatePublished - 1987

Fingerprint

Isotretinoin
Immune System
Pneumonia
Newborn Infant
T-Lymphocytes
Mortality
Infection
Accutane embryopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Thymic Hypoplasia Associated With Isotretinoin Embryopathy. / Cohen, Morris; Rubinstein, Arye; Li, John K.; Nathenson, Gerald.

In: American Journal of Diseases of Children, Vol. 141, No. 3, 1987, p. 263-266.

Research output: Contribution to journalArticle

Cohen, Morris ; Rubinstein, Arye ; Li, John K. ; Nathenson, Gerald. / Thymic Hypoplasia Associated With Isotretinoin Embryopathy. In: American Journal of Diseases of Children. 1987 ; Vol. 141, No. 3. pp. 263-266.
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