The development of a highly amplified immunofluorescence assay and the availability of monoclonal anti‐Thy‐1 antibodies have provided the methodology to reexamine the presence of Thy‐1 antigen on murine lymphohematopoietic cells. The representation of this antigen is not, as previously believed, restricted to the T cell compartment of these cells. It is present on a significant number of mouse bone marrow cells (25–30%), including, as in the rat, multipotential stem cells, prothymocytes and some B cell precursors. Eosinophils and some immature myeloid cells are also antigen‐positive.
ASJC Scopus subject areas
- Immunology and Allergy