Thrombolysis for acute ischemic stroke in patients with cancer: A population study

Santosh B. Murthy, Siddharth Karanth, Shreyansh Shah, Aditi Shastri, Chethan P Venkatasubba Rao, Eric M. Bershad, Jose I. Suarez

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - The safety of thrombolysis for acute stroke in patients with cancer is not well established. Our aim is to study the outcomes after thrombolysis in patients with stroke with cancer. METHODS - Patients with acute ischemic stroke who received thrombolysis were identified from the 2009 and 2010 Nationwide Inpatient Sample. Patients with cancer-associated strokes and noncancer strokes were compared based on demographics, comorbidities, and outcomes. RESULTS - Of the 32 576 strokes treated with thrombolysis, cancer-associated strokes had significantly higher comorbidity indices overall, but fewer vascular risk factors than noncancer strokes. There was no difference in the rates of home discharge and in-hospital mortality, after adjusting for confounders. Subgroup analysis showed that compared with liquid cancers, patients with solid tumors had worse home discharge (odds ratio, 0.178; 95% confidence interval, 0.109-0.290; P

Original languageEnglish (US)
Pages (from-to)3573-3576
Number of pages4
JournalStroke
Volume44
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

Stroke
Population
Neoplasms
Comorbidity
Hospital Mortality
Inpatients
Odds Ratio
Demography
Outcome Assessment (Health Care)
Confidence Intervals
Safety

Keywords

  • Neoplasms
  • Outcomes assessment
  • Stroke
  • Thrombolytic therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Murthy, S. B., Karanth, S., Shah, S., Shastri, A., Rao, C. P. V., Bershad, E. M., & Suarez, J. I. (2013). Thrombolysis for acute ischemic stroke in patients with cancer: A population study. Stroke, 44(12), 3573-3576. https://doi.org/10.1161/STROKEAHA.113.003058

Thrombolysis for acute ischemic stroke in patients with cancer : A population study. / Murthy, Santosh B.; Karanth, Siddharth; Shah, Shreyansh; Shastri, Aditi; Rao, Chethan P Venkatasubba; Bershad, Eric M.; Suarez, Jose I.

In: Stroke, Vol. 44, No. 12, 12.2013, p. 3573-3576.

Research output: Contribution to journalArticle

Murthy, SB, Karanth, S, Shah, S, Shastri, A, Rao, CPV, Bershad, EM & Suarez, JI 2013, 'Thrombolysis for acute ischemic stroke in patients with cancer: A population study', Stroke, vol. 44, no. 12, pp. 3573-3576. https://doi.org/10.1161/STROKEAHA.113.003058
Murthy, Santosh B. ; Karanth, Siddharth ; Shah, Shreyansh ; Shastri, Aditi ; Rao, Chethan P Venkatasubba ; Bershad, Eric M. ; Suarez, Jose I. / Thrombolysis for acute ischemic stroke in patients with cancer : A population study. In: Stroke. 2013 ; Vol. 44, No. 12. pp. 3573-3576.
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