Three-dimensional Models for Cardiac Bioelectricity Simulation: Cell to Organ

Heng Huang, Li Shen, Nha H. Nguyen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Computer models of the heart have become useful tools in improving understanding of cardiac electrical activation at the cellular level, and in analyzing mechanisms of arrhythmias and antiarrhythmic therapies. In this paper, we propose to use spherical harmonic (SPHARM) surface reconstruction and alignment methods to generate curvilinear meshes for finite element models of ventricular anatomy which incorporate detailed structural information. The endocardial and epicardial surfaces are defined by SPHARM, and the volume between these surfaces is divided into nested shells. Consequently, the resulting mesh comprises hexahedral elements. Using this novel SPHARM-based meshing method, the transmembrane potential propagation is simulated, based on FitzHugh—Nagumo reaction—diffusion equations. The dynamic electrical activation propagations are simulated on realistic cardiac data during a heart cycle. The obtained results clearly demonstrate an accurate resolution of the cardiac potential during the excitation. Our novel curvilinear mesh models have a great potential to be used in an improved simulation of cardiovascular pathologies for testing therapy strategies and planning interventions.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalSimulation
Volume83
Issue number4
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Bioelectric phenomena
Spherical Harmonics
Cardiac
Mesh
Three-dimensional
Therapy
Activation
Cell
Chemical activation
Propagation
Simulation
Arrhythmia
Surface Reconstruction
Surface reconstruction
Meshing
Computer Model
Anatomy
Pathology
Reaction-diffusion Equations
Finite Element Model

Keywords

  • Cardiac electrical simulation
  • computer simulation of cardiac excitability
  • curvilinear meshes for finite element

ASJC Scopus subject areas

  • Software
  • Modeling and Simulation
  • Computer Graphics and Computer-Aided Design

Cite this

Three-dimensional Models for Cardiac Bioelectricity Simulation : Cell to Organ. / Huang, Heng; Shen, Li; Nguyen, Nha H.

In: Simulation, Vol. 83, No. 4, 01.01.2007, p. 321-327.

Research output: Contribution to journalArticle

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