Three cases of autoimmune hepatitis in HIV-infected patients

Yoram A. Puius, Lorna M. Dove, Douglas G. Brust, Deena P. Shah, Jay H. Lefkowitch

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Autoimmune hepatitis (AIH) is an uncommon liver disease that has previously been reported only 4 times in HIV-infected patients. Our report describes 3 new cases of AIH, 2 probable, and 1 definite. Two of these cases developed while the patient was virologically suppressed on antiretroviral therapy. Liver biopsy findings were critical in establishing the diagnosis of AIH. Because abnormal liver function tests in HIV-positive patients are often ascribed to antiretroviral medications and/or comorbid conditions, AIH may be underdiagnosed in this population. These cases underscore the value of liver biopsy in evaluating hepatitis of unclear etiology in HIV-positive patients. The clinical course of these cases also suggests that standard immunosuppressive therapy for AIH remains the optimal treatment regimen, even in HIV-positive patients.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalJournal of clinical gastroenterology
Volume42
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

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Keywords

  • Antiretroviral therapy
  • Autoimmune hepatitis
  • Autoimmunity
  • HIV
  • Liver biopsy

ASJC Scopus subject areas

  • Gastroenterology

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