Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. We have treated three advanced CLL patients with theophylline, and seen responses in two. The clinical courses of the responders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.
|Original language||English (US)|
|Number of pages||3|
|Publication status||Published - Apr 1 1999|
- Chronic lymphocytic leukemia
- Cyclic adenosine monophosphate
ASJC Scopus subject areas
- Cancer Research