The use of peroxidase as a tracer in studies of alterations in the blood-brain barrier

A. Hirano, N. H. Becker, H. M. Zimmerman

Research output: Contribution to journalArticle

32 Scopus citations


The distribution of peroxidase in the brain and spinal cord was examined after stab wounds, electroshock-induced convulsions, and experimental allergic encephalomyelitis. In all cases, the tracer was found to have moved from the vasculature into the parenchymatous extracellular spaces. The routes to that site may be via pinocytosis, between altered endothelial junctions or through diffusely-infiltrated endothelial cells.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalJournal of the Neurological Sciences
Issue number3
Publication statusPublished - Mar 1970


ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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