The system epilepsies: A pathophysiological hypothesis

Giuliano Avanzini, Paolo Manganotti, Stefano Meletti, Solomon L. Moshe, Ferruccio Panzica, Peter Wolf, Giuseppe Capovilla

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

Original languageEnglish (US)
Pages (from-to)771-778
Number of pages8
JournalEpilepsia
Volume53
Issue number5
DOIs
StatePublished - May 2012

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Epilepsy
Seizures
Brain
Therapeutics

Keywords

  • Cortico-cortical connections
  • Focal epilepsies
  • Generalized epilepsies
  • Neural systems
  • Thalamo-cortical systems

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Avanzini, G., Manganotti, P., Meletti, S., Moshe, S. L., Panzica, F., Wolf, P., & Capovilla, G. (2012). The system epilepsies: A pathophysiological hypothesis. Epilepsia, 53(5), 771-778. https://doi.org/10.1111/j.1528-1167.2012.03462.x

The system epilepsies : A pathophysiological hypothesis. / Avanzini, Giuliano; Manganotti, Paolo; Meletti, Stefano; Moshe, Solomon L.; Panzica, Ferruccio; Wolf, Peter; Capovilla, Giuseppe.

In: Epilepsia, Vol. 53, No. 5, 05.2012, p. 771-778.

Research output: Contribution to journalArticle

Avanzini, G, Manganotti, P, Meletti, S, Moshe, SL, Panzica, F, Wolf, P & Capovilla, G 2012, 'The system epilepsies: A pathophysiological hypothesis', Epilepsia, vol. 53, no. 5, pp. 771-778. https://doi.org/10.1111/j.1528-1167.2012.03462.x
Avanzini G, Manganotti P, Meletti S, Moshe SL, Panzica F, Wolf P et al. The system epilepsies: A pathophysiological hypothesis. Epilepsia. 2012 May;53(5):771-778. https://doi.org/10.1111/j.1528-1167.2012.03462.x
Avanzini, Giuliano ; Manganotti, Paolo ; Meletti, Stefano ; Moshe, Solomon L. ; Panzica, Ferruccio ; Wolf, Peter ; Capovilla, Giuseppe. / The system epilepsies : A pathophysiological hypothesis. In: Epilepsia. 2012 ; Vol. 53, No. 5. pp. 771-778.
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