The system epilepsies: A pathophysiological hypothesis

Giuliano Avanzini, Paolo Manganotti, Stefano Meletti, Solomon L. Moshé, Ferruccio Panzica, Peter Wolf, Giuseppe Capovilla

Research output: Contribution to journalReview article

100 Scopus citations


We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

Original languageEnglish (US)
Pages (from-to)771-778
Number of pages8
Issue number5
StatePublished - May 2012


  • Cortico-cortical connections
  • Focal epilepsies
  • Generalized epilepsies
  • Neural systems
  • Thalamo-cortical systems

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Avanzini, G., Manganotti, P., Meletti, S., Moshé, S. L., Panzica, F., Wolf, P., & Capovilla, G. (2012). The system epilepsies: A pathophysiological hypothesis. Epilepsia, 53(5), 771-778.