The role of the neutrophil in rheumatoid arthritis

Elizabeth A. Kitsis, G. Weissmann

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Neutrophils acquire lysosomal granules and assembly systems for producing soluble mediators of inflammation during the process of maturation in the bone marrow. Subsequently, they emigrate from the circulation when they become attracted to joint spaces of rheumatoid arthritis patients by chemoattractants such as the complement split product, C5a, and leukotriene B4. Exposure to immune complexes, rheumatoid factor, and cytokines in the synovial fluid results in neutrophil activation with release of granule contents, toxic oxygen metabolites, and proinflammatory products of the arachidonic acid cascade. This process is analogous to a local Arthus reaction in which activation of the complement system is a central event. Some of the inflammatory materials released by this reaction contribute to the cartilage destruction seen in rheumatoid arthritis. Because others are chemoattractants themselves, they perpetuate intraarticular inflammation and permit the predominance of acute inflammatory cells in lesions maintained by chronic inflammation.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalClinical Orthopaedics and Related Research
Issue number265
StatePublished - 1991
Externally publishedYes

Fingerprint

Chemotactic Factors
Rheumatoid Arthritis
Neutrophils
Arthus Reaction
Inflammation
Inflammation Mediators
Neutrophil Activation
Leukotriene B4
Rheumatoid Factor
Complement Activation
Poisons
Synovial Fluid
Antigen-Antibody Complex
Arachidonic Acid
Cartilage
Bone Marrow
Cytokines
Oxygen

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

The role of the neutrophil in rheumatoid arthritis. / Kitsis, Elizabeth A.; Weissmann, G.

In: Clinical Orthopaedics and Related Research, No. 265, 1991, p. 63-72.

Research output: Contribution to journalArticle

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