The role of the chemokines in myocardial ischemia and reperfusion

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Chemokines critically regulate basal and inflammatory leukocyte trafficking and may play a role in angiogenesis. This review summarizes our current understanding of the regulation and potential role of the chemokines in myocardial ischemia and reperfusion. Reperfused myocardial infarction is associated with an inflammatory response leading to leukocyte recruitment, healing and scar formation. Neutrophil chemoattractants, such as the CXC chemokine CXCL8/Interleukin (IL)-8, are upregulated in the infarcted area inducing polymorphonuclear leukocyte infiltration. In addition, mononuclear cell chemoattractants, such as the CC chemokine CCL2/Monocyte Chemoattractant Protein (MCP)-1, are expressed, leading to monocyte and lymphocyte recruitment in the ischemic area. However, chemokines may have additional effects in healing infarcts beyond their leukotactic properties. We have recently described a marked transient induction of the angiostatic CXC chemokine CXCL10/Interferon-γ inducible Protein (IP)- 10 in the infarct. Upregulation of angiostatic factors, such as IP-10, in the first few hours following injury may inhibit premature angiogenesis, until the infarct is debrided and appropriate supportive matrix is formed. Suppression of IP-10 synthesis during the healing phase may allow formation of the wound neovessels, a critical process for infarct healing. Chemokine expression is also noted after a single brief ischemic insult in the absence of myocardial infarction, suggesting a potential role for a chemokine-induced inflammatory response in non-infarctive ischemic cardiomyopathy. Unlike cytokines, which have pleiotropic effects, chemokines have more specific cellular targets. Understanding of their role in myocardial infarction may allow us to design specific therapeutic strategies aiming at optimizing cardiac repair and preventing ventricular remodeling.

Original languageEnglish (US)
Pages (from-to)163-174
Number of pages12
JournalCurrent Vascular Pharmacology
Volume2
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Myocardial Reperfusion
Chemokines
Myocardial Ischemia
Chemokine CXCL10
CXC Chemokines
Chemokine CCL2
Chemotactic Factors
Myocardial Infarction
Interleukin-8
Neutrophils
Leukocytes
CC Chemokines
Ventricular Remodeling
Wounds and Injuries
Cardiomyopathies
Cicatrix
Monocytes
Proteins
Up-Regulation
Lymphocytes

Keywords

  • Chemokines
  • Endothelium
  • Heart
  • Inflammation
  • Interleukin-8
  • Ischemia/reperfusion
  • Leukocyte
  • MCP-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

The role of the chemokines in myocardial ischemia and reperfusion. / Frangogiannis, Nikolaos G.

In: Current Vascular Pharmacology, Vol. 2, No. 2, 04.2004, p. 163-174.

Research output: Contribution to journalArticle

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