The role of stem cells in treating coronary artery disease in 2018

Research output: Contribution to journalReview articlepeer-review


The last decade has witnessed the publication of a number of stem cell clinical trials, primarily using bone marrow-derived cells as the injected cell. Much has been learned through these “first-generation” clinical trials. The advances in our understanding include the following: (1) cell therapy is safe; (2) cell therapy has been mildly effective; and (3) human bone marrow-derived stem cells do not transdifferentiate into cardiomyocytes or new blood vessels. The primary mechanism of action for cell therapy is now believed to be through paracrine effects that include the release of cytokines, chemokines, and growth factors that inhibit apoptosis and fibrosis, enhance contractility, and activate endogenous regenerative mechanisms through endogenous circulating or site-specific stem cells. The current direction for clinical trials includes the use of stem cells capable of cardiac lineage.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalIndian Journal of Thoracic and Cardiovascular Surgery
StatePublished - Dec 20 2018


  • Bone marrow mononuclear cells
  • Cardiac stem cells
  • Heart failure

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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