The role of somatic hypermutation in the generation of antibody diversity

Deborah L. French, Reuven Laskov, Matthew D. Scharff

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

The immune system is capable of establishing an enormous repertoire of antibodies before its first contact with antigen. Most antibodies that express germ-line sequences are of relatively low affinity. Once antigen enters the system, it stimulates a somatic mutational mechanism that generates antibodies of higher affinity and selects for the expression of those antibodies to produce a more effective immune response. The details of the mechanism and regulaton of somatic hypermutation remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)1152-1157
Number of pages6
JournalScience
Volume244
Issue number4909
StatePublished - 1989

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Antibody Diversity
Antibodies
Antigens
Antibody Affinity
Germ Cells
Immune System

ASJC Scopus subject areas

  • General

Cite this

The role of somatic hypermutation in the generation of antibody diversity. / French, Deborah L.; Laskov, Reuven; Scharff, Matthew D.

In: Science, Vol. 244, No. 4909, 1989, p. 1152-1157.

Research output: Contribution to journalArticle

French, DL, Laskov, R & Scharff, MD 1989, 'The role of somatic hypermutation in the generation of antibody diversity', Science, vol. 244, no. 4909, pp. 1152-1157.
French, Deborah L. ; Laskov, Reuven ; Scharff, Matthew D. / The role of somatic hypermutation in the generation of antibody diversity. In: Science. 1989 ; Vol. 244, No. 4909. pp. 1152-1157.
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