The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection

Andréa Pereira De Souza, Ryan Sieberg, Hua Li, Hannah R. Cahill, Dazhi Zhao, Tania C. Araújo-Jorge, Herbert B. Tanowitz, Linda A. Jelicks

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to non-invasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruzi-infected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased compared with infected mice fed with normal unsupplemented chow and was not significantly different from intestinal motility in uninfected mice. We suggest that Se may be used to modulate the inflammatory, immunological, and/or antioxidant responses involved in intestinal disturbances caused by T. cruzi infection.

Original languageEnglish (US)
Pages (from-to)1293-1298
Number of pages6
JournalParasitology Research
Volume106
Issue number6
DOIs
StatePublished - May 2010

Fingerprint

gastrointestinal motility
Gastrointestinal Motility
Selenium
selenium
animal models
Trypanosoma cruzi
mice
Infection
infection
gastrointestinal system
Intestines
Gastrointestinal Tract
intestines
magnetic resonance imaging
Drinking Water
drinking water
Brazil
Dilatation
Antioxidants
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

De Souza, A. P., Sieberg, R., Li, H., Cahill, H. R., Zhao, D., Araújo-Jorge, T. C., ... Jelicks, L. A. (2010). The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection. Parasitology Research, 106(6), 1293-1298. https://doi.org/10.1007/s00436-010-1794-1

The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection. / De Souza, Andréa Pereira; Sieberg, Ryan; Li, Hua; Cahill, Hannah R.; Zhao, Dazhi; Araújo-Jorge, Tania C.; Tanowitz, Herbert B.; Jelicks, Linda A.

In: Parasitology Research, Vol. 106, No. 6, 05.2010, p. 1293-1298.

Research output: Contribution to journalArticle

De Souza, AP, Sieberg, R, Li, H, Cahill, HR, Zhao, D, Araújo-Jorge, TC, Tanowitz, HB & Jelicks, LA 2010, 'The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection', Parasitology Research, vol. 106, no. 6, pp. 1293-1298. https://doi.org/10.1007/s00436-010-1794-1
De Souza, Andréa Pereira ; Sieberg, Ryan ; Li, Hua ; Cahill, Hannah R. ; Zhao, Dazhi ; Araújo-Jorge, Tania C. ; Tanowitz, Herbert B. ; Jelicks, Linda A. / The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection. In: Parasitology Research. 2010 ; Vol. 106, No. 6. pp. 1293-1298.
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