The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection

Andréa Pereira De Souza, Ryan Sieberg, Hua Li, Hannah R. Cahill, Dazhi Zhao, Tania C. Araújo-Jorge, Herbert B. Tanowitz, Linda A. Jelicks

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to non-invasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruzi-infected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased compared with infected mice fed with normal unsupplemented chow and was not significantly different from intestinal motility in uninfected mice. We suggest that Se may be used to modulate the inflammatory, immunological, and/or antioxidant responses involved in intestinal disturbances caused by T. cruzi infection.

Original languageEnglish (US)
Pages (from-to)1293-1298
Number of pages6
JournalParasitology Research
Volume106
Issue number6
DOIs
StatePublished - May 1 2010

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ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

Cite this

De Souza, A. P., Sieberg, R., Li, H., Cahill, H. R., Zhao, D., Araújo-Jorge, T. C., Tanowitz, H. B., & Jelicks, L. A. (2010). The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection. Parasitology Research, 106(6), 1293-1298. https://doi.org/10.1007/s00436-010-1794-1