The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production

Matthew D. Scharff, Ronald A. DePinho, Samuel Behar, Cori Beychok, Seung Uon Shin, Deborah French

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The hybridoma technology has made it possible to sample the B-cell repertoire and to generate monoclonal antibodies which can be analyzed for their specificity and idiotypy. Using the recombinant DNA technology, the structure of the genes which encode those antibodies can be analyzed. The knowledge gained from the application of these techniques has made it possible to pose specific questions about the origins of autoantibodies.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalCellular Immunology
Volume99
Issue number1
DOIs
StatePublished - Apr 15 1986

Fingerprint

Recombinant DNA
Autoantibodies
Monoclonal Antibodies
Technology
Hybridomas
B-Lymphocytes
Antibodies
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. / Scharff, Matthew D.; DePinho, Ronald A.; Behar, Samuel; Beychok, Cori; Shin, Seung Uon; French, Deborah.

In: Cellular Immunology, Vol. 99, No. 1, 15.04.1986, p. 29-37.

Research output: Contribution to journalArticle

Scharff, Matthew D. ; DePinho, Ronald A. ; Behar, Samuel ; Beychok, Cori ; Shin, Seung Uon ; French, Deborah. / The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. In: Cellular Immunology. 1986 ; Vol. 99, No. 1. pp. 29-37.
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