@article{7e13c9c8bd654d5eb30c7bdad72f6de3,
title = "The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production",
abstract = "The hybridoma technology has made it possible to sample the B-cell repertoire and to generate monoclonal antibodies which can be analyzed for their specificity and idiotypy. Using the recombinant DNA technology, the structure of the genes which encode those antibodies can be analyzed. The knowledge gained from the application of these techniques has made it possible to pose specific questions about the origins of autoantibodies.",
author = "Scharff, {Matthew D.} and DePinho, {Ronald A.} and Samuel Behar and Cori Beychok and Shin, {Seung Uon} and Deborah French",
note = "Funding Information: Our own work referred to in this review is supported by grants from the NIH (A105231, AI10702), NSF (PCM-83 16150), and ACS (IM-3 17). R.A.D. is the recipient of a Physician Scientist Award from the NIAD (AI 00602). S.B. is a medical scientist trainee supported by a grant from NIGMS (T32GM7288). C.B. and S.-U.S. are supported by a training grant from the NC1 (CA09173). D.F. is supported by a fellowship from the New York Heart Association. We thank Lori Feldman for preparing the illustrations, and Rosalie Spata for preparing the manuscript.",
year = "1986",
month = apr,
day = "15",
doi = "10.1016/0008-8749(86)90212-1",
language = "English (US)",
volume = "99",
pages = "29--37",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",
}