The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes

Swapnil N. Rajpathak, Marc J. Gunter, Judith Wylie-Rosett, Gloria Y.F. Ho, Robert C. Kaplan, Radhika Muzumdar, Thomas E. Rohan, Howard D. Strickler

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations

Abstract

This review addresses the possible role of the insulin-like growth factor (IGF)-axis in normal glucose homoeostasis and in the etiopathogenesis of type 2 diabetes. IGF-I, a peptide hormone, shares amino acid sequence homology with insulin and has insulin-like activity; most notably, the promotion of glucose uptake by peripheral tissues. Type 2 diabetes as well as pre-diabetic states, including impaired fasting glucose and impaired glucose tolerance, are associated cross-sectionally with altered circulating levels of IGF-I and its binding proteins (IGFBPs). Administration of recombinant human IGF-I has been reported to improve insulin sensitivity in healthy individuals as well as in patients with insulin resistance and type 2 diabetes. Further, IGF-I may have beneficial effects on systemic inflammation, a risk factor for type 2 diabetes, and on pancreatic β-cell mass and function. There is considerable inter-individual heterogeneity in endogenous levels of IGF-I and its binding proteins; however, the relationship between these variations and the risk of developing type 2 diabetes has not been extensively investigated. Large prospective studies are required to evaluate this association.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalDiabetes/Metabolism Research and Reviews
Volume25
Issue number1
DOIs
StatePublished - Jun 4 2009

Keywords

  • Diabetes
  • Glucose
  • IGFBP
  • Insulin-like growth factor (IGF)-I

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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