The role of electron microscopy in neuropathology: A personal historical note

Asao Hirano

Research output: Contribution to journalArticle

9 Scopus citations


The electron microscope has been an essential instrument for elucidating the morphology of cells and tissue. Fine structural investigation of nervous tissue has disclosed numerous new findings, which were once invisible. In this communication I present my personal perspective on the role of electron microscopy in neuropathology through the presentation of selected electron microscopic projects engaged in our institution. These include brain edema, structural analysis of the myelin in the central nervous system, endodermal cysts in the central nervous system, aberrant synaptic development, toxoplasmosis in AIDS, and Hirano bodies.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalActa neuropathologica
Issue number1
Publication statusPublished - Jan 1 2005



  • Cyst
  • Electron microscopy
  • Neuropathology
  • Synapse

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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