The role of cyclic AMP in the phosphorylation of proteins in human erythrocyte membranes

Charles S. Rubin, Ora M. Rosen

Research output: Contribution to journalArticle

81 Scopus citations


Three protein components of human erythrocyte membranes served as substrates for membrane-bound protein kinase. Cyclic AMP stimulated the rates of phosphorylation of two polypeptides, but the phosphorylation of the principal phosphate-acceptor was not enhanced by the cyclic nucleotide. These observations demonstrate the presence of cyclic AMP-dependent protein kinase and its homologous substrates in erythrocyte membranes and suggest that cyclic AMP could mediate alterations in the properties of membranes.

Original languageEnglish (US)
Pages (from-to)421-429
Number of pages9
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - Jan 23 1973


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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