Three protein components of human erythrocyte membranes served as substrates for membrane-bound protein kinase. Cyclic AMP stimulated the rates of phosphorylation of two polypeptides, but the phosphorylation of the principal phosphate-acceptor was not enhanced by the cyclic nucleotide. These observations demonstrate the presence of cyclic AMP-dependent protein kinase and its homologous substrates in erythrocyte membranes and suggest that cyclic AMP could mediate alterations in the properties of membranes.
|Original language||English (US)|
|Number of pages||9|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Jan 23 1973|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology