The role of cyclic AMP in the phosphorylation of proteins in human erythrocyte membranes

Charles S. Rubin, Ora M. Rosen

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Three protein components of human erythrocyte membranes served as substrates for membrane-bound protein kinase. Cyclic AMP stimulated the rates of phosphorylation of two polypeptides, but the phosphorylation of the principal phosphate-acceptor was not enhanced by the cyclic nucleotide. These observations demonstrate the presence of cyclic AMP-dependent protein kinase and its homologous substrates in erythrocyte membranes and suggest that cyclic AMP could mediate alterations in the properties of membranes.

Original languageEnglish (US)
Pages (from-to)421-429
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume50
Issue number2
DOIs
StatePublished - Jan 23 1973

Fingerprint

Phosphorylation
Erythrocyte Membrane
Cyclic AMP
Membranes
Cyclic Nucleotides
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Membrane Proteins
Proteins
Phosphates
Peptides
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The role of cyclic AMP in the phosphorylation of proteins in human erythrocyte membranes. / Rubin, Charles S.; Rosen, Ora M.

In: Biochemical and Biophysical Research Communications, Vol. 50, No. 2, 23.01.1973, p. 421-429.

Research output: Contribution to journalArticle

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