Abstract
Tuberculosis (TB) remains a serious threat to public health, causing 2 million deaths annually world-wide. The control of TB has been hindered by the requirement of long duration of treatment involving multiple chemotherapeutic agents, the increased susceptibility to Mycobacterium Tuberculosis infection in the HIV-infected population, and the development of multi-drug resistant and extensively resistant strains of tubercle bacilli. An efficacious and cost-efficient way to control TB is the development of effective anti-TB vaccines. This measure requires thorough understanding of the immune response to M. Tuberculosis. While the role of cell-mediated immunity in the development of protective immune response to the tubercle bacillus has been well established, the role of B cells in this process is not clearly understood. Emerging evidence suggests that B cells and humoral immunity can modulate the immune response to various intracellular pathogens, including M. Tuberculosis. These lymphocytes form conspicuous aggregates in the lungs of tuberculous humans, non-human primates, and mice, which display features of germinal center B cells. In murine TB, it has been shown that B cells can regulate the level of granulomatous reaction, cytokine production, and the T cell response. This chapter discusses the potential mechanisms by which specific functions of B cells and humoral immunity can shape the immune response to intracellular pathogens in general, and to M. Tuberculosis in particular. Knowledge of the B cell-mediated immune response to M. Tuberculosis may lead to the design of novel strategies, including the development of effective vaccines, to better control TB.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 225-250 |
| Number of pages | 26 |
| Volume | 783 |
| ISBN (Print) | 9781461461104 |
| DOIs | |
| State | Published - 2013 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 783 |
| ISSN (Print) | 00652598 |
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Keywords
- Antibodies
- Antigen presentation
- B cells
- Cytokine production
- Cytokines
- Fcc receptors
- Granuloma
- Humoral immunity
- Immunopathology
- Macrophages
- Myocobacterium Tuberculosis
- Neutrophils
- T cell responses
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
The role of B cells and humoral immunity in mycobacterium Tuberculosis infection. / Kozakiewicz, Lee; Phuah, Jiayao; Flynn, Joanne; Chan, John.
Advances in Experimental Medicine and Biology. Vol. 783 Springer New York LLC, 2013. p. 225-250 (Advances in Experimental Medicine and Biology; Vol. 783).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The role of B cells and humoral immunity in mycobacterium Tuberculosis infection
AU - Kozakiewicz, Lee
AU - Phuah, Jiayao
AU - Flynn, Joanne
AU - Chan, John
PY - 2013
Y1 - 2013
N2 - Tuberculosis (TB) remains a serious threat to public health, causing 2 million deaths annually world-wide. The control of TB has been hindered by the requirement of long duration of treatment involving multiple chemotherapeutic agents, the increased susceptibility to Mycobacterium Tuberculosis infection in the HIV-infected population, and the development of multi-drug resistant and extensively resistant strains of tubercle bacilli. An efficacious and cost-efficient way to control TB is the development of effective anti-TB vaccines. This measure requires thorough understanding of the immune response to M. Tuberculosis. While the role of cell-mediated immunity in the development of protective immune response to the tubercle bacillus has been well established, the role of B cells in this process is not clearly understood. Emerging evidence suggests that B cells and humoral immunity can modulate the immune response to various intracellular pathogens, including M. Tuberculosis. These lymphocytes form conspicuous aggregates in the lungs of tuberculous humans, non-human primates, and mice, which display features of germinal center B cells. In murine TB, it has been shown that B cells can regulate the level of granulomatous reaction, cytokine production, and the T cell response. This chapter discusses the potential mechanisms by which specific functions of B cells and humoral immunity can shape the immune response to intracellular pathogens in general, and to M. Tuberculosis in particular. Knowledge of the B cell-mediated immune response to M. Tuberculosis may lead to the design of novel strategies, including the development of effective vaccines, to better control TB.
AB - Tuberculosis (TB) remains a serious threat to public health, causing 2 million deaths annually world-wide. The control of TB has been hindered by the requirement of long duration of treatment involving multiple chemotherapeutic agents, the increased susceptibility to Mycobacterium Tuberculosis infection in the HIV-infected population, and the development of multi-drug resistant and extensively resistant strains of tubercle bacilli. An efficacious and cost-efficient way to control TB is the development of effective anti-TB vaccines. This measure requires thorough understanding of the immune response to M. Tuberculosis. While the role of cell-mediated immunity in the development of protective immune response to the tubercle bacillus has been well established, the role of B cells in this process is not clearly understood. Emerging evidence suggests that B cells and humoral immunity can modulate the immune response to various intracellular pathogens, including M. Tuberculosis. These lymphocytes form conspicuous aggregates in the lungs of tuberculous humans, non-human primates, and mice, which display features of germinal center B cells. In murine TB, it has been shown that B cells can regulate the level of granulomatous reaction, cytokine production, and the T cell response. This chapter discusses the potential mechanisms by which specific functions of B cells and humoral immunity can shape the immune response to intracellular pathogens in general, and to M. Tuberculosis in particular. Knowledge of the B cell-mediated immune response to M. Tuberculosis may lead to the design of novel strategies, including the development of effective vaccines, to better control TB.
KW - Antibodies
KW - Antigen presentation
KW - B cells
KW - Cytokine production
KW - Cytokines
KW - Fcc receptors
KW - Granuloma
KW - Humoral immunity
KW - Immunopathology
KW - Macrophages
KW - Myocobacterium Tuberculosis
KW - Neutrophils
KW - T cell responses
UR - http://www.scopus.com/inward/record.url?scp=84879545297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879545297&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-6111-1_12
DO - 10.1007/978-1-4614-6111-1_12
M3 - Chapter
C2 - 23468112
AN - SCOPUS:84879545297
SN - 9781461461104
VL - 783
T3 - Advances in Experimental Medicine and Biology
SP - 225
EP - 250
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -