The role of B cells and humoral immunity in mycobacterium Tuberculosis infection

Lee Kozakiewicz, Jiayao Phuah, Joanne Flynn, John Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

66 Citations (Scopus)

Abstract

Tuberculosis (TB) remains a serious threat to public health, causing 2 million deaths annually world-wide. The control of TB has been hindered by the requirement of long duration of treatment involving multiple chemotherapeutic agents, the increased susceptibility to Mycobacterium Tuberculosis infection in the HIV-infected population, and the development of multi-drug resistant and extensively resistant strains of tubercle bacilli. An efficacious and cost-efficient way to control TB is the development of effective anti-TB vaccines. This measure requires thorough understanding of the immune response to M. Tuberculosis. While the role of cell-mediated immunity in the development of protective immune response to the tubercle bacillus has been well established, the role of B cells in this process is not clearly understood. Emerging evidence suggests that B cells and humoral immunity can modulate the immune response to various intracellular pathogens, including M. Tuberculosis. These lymphocytes form conspicuous aggregates in the lungs of tuberculous humans, non-human primates, and mice, which display features of germinal center B cells. In murine TB, it has been shown that B cells can regulate the level of granulomatous reaction, cytokine production, and the T cell response. This chapter discusses the potential mechanisms by which specific functions of B cells and humoral immunity can shape the immune response to intracellular pathogens in general, and to M. Tuberculosis in particular. Knowledge of the B cell-mediated immune response to M. Tuberculosis may lead to the design of novel strategies, including the development of effective vaccines, to better control TB.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages225-250
Number of pages26
Volume783
ISBN (Print)9781461461104
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume783
ISSN (Print)00652598

Fingerprint

Mycobacterium Infections
Humoral Immunity
Mycobacterium tuberculosis
B-Lymphocytes
Cells
Tuberculosis
Pathogens
Bacilli
Bacillus
Tuberculosis Vaccines
Germinal Center
T-cells
Lymphocytes
Public health
Cellular Immunity
Primates
Vaccines
Public Health
HIV
Cytokines

Keywords

  • Antibodies
  • Antigen presentation
  • B cells
  • Cytokine production
  • Cytokines
  • Fcc receptors
  • Granuloma
  • Humoral immunity
  • Immunopathology
  • Macrophages
  • Myocobacterium Tuberculosis
  • Neutrophils
  • T cell responses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kozakiewicz, L., Phuah, J., Flynn, J., & Chan, J. (2013). The role of B cells and humoral immunity in mycobacterium Tuberculosis infection. In Advances in Experimental Medicine and Biology (Vol. 783, pp. 225-250). (Advances in Experimental Medicine and Biology; Vol. 783). Springer New York LLC. https://doi.org/10.1007/978-1-4614-6111-1_12

The role of B cells and humoral immunity in mycobacterium Tuberculosis infection. / Kozakiewicz, Lee; Phuah, Jiayao; Flynn, Joanne; Chan, John.

Advances in Experimental Medicine and Biology. Vol. 783 Springer New York LLC, 2013. p. 225-250 (Advances in Experimental Medicine and Biology; Vol. 783).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kozakiewicz, L, Phuah, J, Flynn, J & Chan, J 2013, The role of B cells and humoral immunity in mycobacterium Tuberculosis infection. in Advances in Experimental Medicine and Biology. vol. 783, Advances in Experimental Medicine and Biology, vol. 783, Springer New York LLC, pp. 225-250. https://doi.org/10.1007/978-1-4614-6111-1_12
Kozakiewicz L, Phuah J, Flynn J, Chan J. The role of B cells and humoral immunity in mycobacterium Tuberculosis infection. In Advances in Experimental Medicine and Biology. Vol. 783. Springer New York LLC. 2013. p. 225-250. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-6111-1_12
Kozakiewicz, Lee ; Phuah, Jiayao ; Flynn, Joanne ; Chan, John. / The role of B cells and humoral immunity in mycobacterium Tuberculosis infection. Advances in Experimental Medicine and Biology. Vol. 783 Springer New York LLC, 2013. pp. 225-250 (Advances in Experimental Medicine and Biology).
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