The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups

S. G. Xu, D. S. Garant, E. F. Sperber, Solomon L. Moshe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The substantia nigra γ-aminobutyric acid (GABA) system is crucial for seizure control. Our previous work indicates that in 16-day-old rat pups, nigral administration of the GABAA receptor agonist muscimol facilities flurothyl-induced seizures, whereas it suppresses seizures in adult rats. To determine whether the proconvulsant effect of muscimol in rat pups may be mediated by nigral GABAA receptors, in the present study we applied a selective GABAA receptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP). Bilateral nigral infusions of THIP (500 or 700 ng) significantly decreased the thresholds for flurothyl seizures in a dose-dependent fashion. Doses of 350 ng or less did not significantly modify the susceptibility to seizures. An anticonvulsant action of THIP could not be detected at any dose. Administration of an effective THIP dose (500 ng) 2 mm dorsal to the SNR had no influence on seizures. These findings suggest that in rat pups the proconvulsant effect of nigral GABAA receptor agonists may be attributed to unique pharmacologic characteristics of GABAA receptors during development.

Original languageEnglish (US)
Pages (from-to)275-277
Number of pages3
JournalDevelopmental Brain Research
Volume68
Issue number2
DOIs
StatePublished - Aug 21 1992

Fingerprint

Flurothyl
Substantia Nigra
Seizures
GABA-A Receptor Agonists
Muscimol
GABA-A Receptors
Aminobutyrates
Anticonvulsants
gamma-Aminobutyric Acid
gaboxadol

Keywords

  • Convulsion
  • Rat
  • Seizure
  • Substantia nigra
  • THIP
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups. / Xu, S. G.; Garant, D. S.; Sperber, E. F.; Moshe, Solomon L.

In: Developmental Brain Research, Vol. 68, No. 2, 21.08.1992, p. 275-277.

Research output: Contribution to journalArticle

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