Abstract
Electron dense material was observed in the extracellular spaces between adjacent components of the Schmidt-Lanterman clefts and between lateral loops at the paranodes in some of the heavily myelinated fibers of the anterior roots and peripheral nerves of a patient with amyotrophic lateral sclerosis. Similar deposits were seen in tissue derived from patients who died with no neurological disease. These deposits were also present in the extracellular spaces of the endoneurium and beneath the outer cytoplasmic collar of the sheath, but did not penetrate the intraperiod line of the compact myelin or the periaxonal space and the lateral loops tended to remain in contact with the axon. The findings suggest that a pathway exists between the extracellular spaces outside the sheath to the innermost portion of the sheath but that the periaxonal space is resistant to the penetration of the extraneous material.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-38 |
| Number of pages | 5 |
| Journal | Acta Neuropathologica |
| Volume | 58 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1982 |
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Keywords
- Myelinated nerve fiber
- Periaxonal space
- Schmidt-Lanterman cleft
ASJC Scopus subject areas
- Neuroscience(all)
- Pathology and Forensic Medicine
- Clinical Neurology
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Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The permeability of the extracellular spaces at the Schmidt-Lanterman clefts and paranodes in peripheral myelin sheaths
AU - Hirano, A.
PY - 1982/3
Y1 - 1982/3
N2 - Electron dense material was observed in the extracellular spaces between adjacent components of the Schmidt-Lanterman clefts and between lateral loops at the paranodes in some of the heavily myelinated fibers of the anterior roots and peripheral nerves of a patient with amyotrophic lateral sclerosis. Similar deposits were seen in tissue derived from patients who died with no neurological disease. These deposits were also present in the extracellular spaces of the endoneurium and beneath the outer cytoplasmic collar of the sheath, but did not penetrate the intraperiod line of the compact myelin or the periaxonal space and the lateral loops tended to remain in contact with the axon. The findings suggest that a pathway exists between the extracellular spaces outside the sheath to the innermost portion of the sheath but that the periaxonal space is resistant to the penetration of the extraneous material.
AB - Electron dense material was observed in the extracellular spaces between adjacent components of the Schmidt-Lanterman clefts and between lateral loops at the paranodes in some of the heavily myelinated fibers of the anterior roots and peripheral nerves of a patient with amyotrophic lateral sclerosis. Similar deposits were seen in tissue derived from patients who died with no neurological disease. These deposits were also present in the extracellular spaces of the endoneurium and beneath the outer cytoplasmic collar of the sheath, but did not penetrate the intraperiod line of the compact myelin or the periaxonal space and the lateral loops tended to remain in contact with the axon. The findings suggest that a pathway exists between the extracellular spaces outside the sheath to the innermost portion of the sheath but that the periaxonal space is resistant to the penetration of the extraneous material.
KW - Myelinated nerve fiber
KW - Periaxonal space
KW - Schmidt-Lanterman cleft
UR - http://www.scopus.com/inward/record.url?scp=0019967323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019967323&partnerID=8YFLogxK
U2 - 10.1007/BF00692695
DO - 10.1007/BF00692695
M3 - Article
C2 - 7136514
AN - SCOPUS:0019967323
VL - 58
SP - 34
EP - 38
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 0001-6322
IS - 1
ER -