The periaxonal space in an experimental model of neuropathy

The mutant Syrian hamster with hindleg paralysis

Asao Hirano, Herbert M. Dembitzer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The periaxonal space of peripheral myelinated axons was studied in the mutant Syrian hamster with hindleg paralysis, an experimental model of neuropathy. Despite pronounced alterations of the axon and the surrounding sheath, sometimes leading to demyelination, the periaxonal space showed remarkable resistance to change in most instances. When the space was widened as the result of the infiltration of extracellular fluid, the axon was found at the periphery of the enlarged inner perimeter of the sheath. Even under these extreme conditions the axon maintained a close to normal distance from the inner collar of cytoplasm. The significance of these findings with regard to both the normal anatomical relationship within the sheath and to the mechanisms of demyelination are discussed.

Original languageEnglish (US)
Pages (from-to)261-269
Number of pages9
JournalJournal of Neurocytology
Volume10
Issue number2
DOIs
StatePublished - Apr 1981

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Mesocricetus
Paralysis
Axons
Theoretical Models
Demyelinating Diseases
Extracellular Fluid
Cytoplasm

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

Cite this

The periaxonal space in an experimental model of neuropathy : The mutant Syrian hamster with hindleg paralysis. / Hirano, Asao; Dembitzer, Herbert M.

In: Journal of Neurocytology, Vol. 10, No. 2, 04.1981, p. 261-269.

Research output: Contribution to journalArticle

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