The nucleus accumbens as part of a basal ganglia action selection circuit

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Background: The nucleus accumbens is the ventral extent of the striatum, the main input nucleus of the basal ganglia. Recent hypotheses propose that the accumbens and its dopamine projection from the midbrain contribute to appetitive behaviors required to obtain reward. However, the specific nature of this contribution is unclear. In contrast, significant advances have been made in understanding the role of the dorsal striatum in action selection and decision making. Objective: In order to develop a hypothesis of the role of nucleus accumbens dopamine in action selection, the physiology and behavioral pharmacology of the nucleus accumbens are compared to those of the dorsal striatum. Hypotheses: Three hypotheses concerning the role of dopamine in these structures are proposed: (1) that dopamine release in the dorsal striatum serves to facilitate the ability to respond appropriately to temporally predictable stimuli (that is, stimuli that are so predictable that animals engage in anticipatory behavior just prior to the stimulus); (2) that dopamine in the nucleus accumbens facilitates the ability to respond to temporally unpredictable stimuli (which require interruption of ongoing behavior); and (3) that accumbens neurons participate in action selection in response to such stimuli by virtue of their direct (monosynaptic inhibitory) and indirect (polysynaptic excitatory) projections to basal ganglia output nuclei.

Original languageEnglish (US)
Pages (from-to)521-550
Number of pages30
JournalPsychopharmacology
Volume191
Issue number3
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Nucleus Accumbens
Basal Ganglia
Dopamine
Aptitude
Appetitive Behavior
Mesencephalon
Reward
Decision Making
Pharmacology
Neurons

Keywords

  • Choice
  • Decision-making
  • Dopamine
  • Incentive
  • Operant
  • Reward
  • Striatum

ASJC Scopus subject areas

  • Pharmacology

Cite this

The nucleus accumbens as part of a basal ganglia action selection circuit. / Nicola, Saleem M.

In: Psychopharmacology, Vol. 191, No. 3, 04.2007, p. 521-550.

Research output: Contribution to journalArticle

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