The Neuroanatomy of Serotonin (5-HT) Dysregulation in Obsessive-Compulsive Disorder

Gregory Grove, Jeremy Coplan, Lisa Margolin, Eric Hollander

Research output: Contribution to journalArticle

3 Scopus citations


A growing body of evidence suggests that obsessive-compulsive disorder (OCD) may be associated with alterations of the serotonin (5-HT) system and that the dorsal raphe nucleus (DRN) may play a role in OCD. In this report, we review this evidence and explore the possible roles of 5-HT and DRN as they relate to OCD.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalCNS Spectrums
Issue number2
Publication statusPublished - 1996
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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