The mitochondrial death pathway and cardiac myocyte apoptosis

Michael T. Crow, Kartik Mani, Young Jae Nam, Richard N. Kitsis

Research output: Contribution to journalArticle

437 Citations (Scopus)

Abstract

Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.

Original languageEnglish (US)
Pages (from-to)957-970
Number of pages14
JournalCirculation Research
Volume95
Issue number10
DOIs
StatePublished - Nov 12 2004

Fingerprint

Cardiac Myocytes
Heart Failure
Apoptosis
Cell Surface Receptors
Endoplasmic Reticulum
Rodentia
Heart Diseases
Mitochondria
Myocardial Infarction
Pathology

Keywords

  • Apoptosis
  • Apoptosome
  • Bcl-2
  • Caspase
  • Cell death
  • Death-inducing signaling complex
  • Heart failure
  • Ischemia
  • Mitochondria
  • Necrosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

The mitochondrial death pathway and cardiac myocyte apoptosis. / Crow, Michael T.; Mani, Kartik; Nam, Young Jae; Kitsis, Richard N.

In: Circulation Research, Vol. 95, No. 10, 12.11.2004, p. 957-970.

Research output: Contribution to journalArticle

Crow, Michael T. ; Mani, Kartik ; Nam, Young Jae ; Kitsis, Richard N. / The mitochondrial death pathway and cardiac myocyte apoptosis. In: Circulation Research. 2004 ; Vol. 95, No. 10. pp. 957-970.
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