The menin gene

Steven K. Libutti, Hsin Chieh Jennifer Shen

Research output: Contribution to journalArticle

Abstract

Multiple endocrine neoplasia type I (MEN-1) is an autosomal dominant syndrome featuring tumors of endocrine origin. Heterozygous germline mutations in the MEN-1 tumor suppressor gene predispose MEN-1 patients to tumor development, mainly in parathyroid, pancreatic islet cells, and the anterior pituitary gland. Since the MEN-1-encoded protein, menin, is ubiquitously expressed, the endocrine-specific nature in MEN-1 patients remains unexplained. This chapter provides an overview of the MEN-1 gene, including patterns of mutations identified since its discovery in 1997. Different menin-interacting protein partners and menin's proposed molecular functions are also discussed. Lastly, various animal models of MEN-1 are described in detail. While analyses utilizing genetic, biochemical, and physiological techniques have led to a better understanding of menin's mechanisms of action, much is yet to be elucidated about menin's role in MEN-1 tumorigenesis.

Original languageEnglish (US)
Pages (from-to)273-286
Number of pages14
JournalCancer Treatment and Research
Volume153
DOIs
StatePublished - 2010

Fingerprint

Multiple Endocrine Neoplasia Type 1
Genes
Islets of Langerhans
Anterior Pituitary Gland
Germ-Line Mutation
Tumor Suppressor Genes
Molecular Biology
Neoplasms
Carcinogenesis
Proteins
Animal Models
Mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Libutti, S. K., & Shen, H. C. J. (2010). The menin gene. Cancer Treatment and Research, 153, 273-286. https://doi.org/10.1007/978-1-4419-0857-5_15

The menin gene. / Libutti, Steven K.; Shen, Hsin Chieh Jennifer.

In: Cancer Treatment and Research, Vol. 153, 2010, p. 273-286.

Research output: Contribution to journalArticle

Libutti, SK & Shen, HCJ 2010, 'The menin gene', Cancer Treatment and Research, vol. 153, pp. 273-286. https://doi.org/10.1007/978-1-4419-0857-5_15
Libutti, Steven K. ; Shen, Hsin Chieh Jennifer. / The menin gene. In: Cancer Treatment and Research. 2010 ; Vol. 153. pp. 273-286.
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