The menin gene

Steven K. Libutti, Hsin Chieh Jennifer Shen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple endocrine neoplasia type I (MEN-1) is an autosomal dominant syndrome featuring tumors of endocrine origin. Heterozygous germline mutations in the MEN-1 tumor suppressor gene predispose MEN-1 patients to tumor development, mainly in parathyroid, pancreatic islet cells, and the anterior pituitary gland. Since the MEN-1-encoded protein, menin, is ubiquitously expressed, the endocrine-specific nature in MEN-1 patients remains unexplained. This chapter provides an overview of the MEN-1 gene, including patterns of mutations identified since its discovery in 1997. Different menin-interacting protein partners and menin's proposed molecular functions are also discussed. Lastly, various animal models of MEN-1 are described in detail. While analyses utilizing genetic, biochemical, and physiological techniques have led to a better understanding of menin's mechanisms of action, much is yet to be elucidated about menin's role in MEN-1 tumorigenesis.

Original languageEnglish (US)
Title of host publicationEndocrine Neoplasia
EditorsCord Sturgeon
Pages273-286
Number of pages14
DOIs
StatePublished - Jan 1 2010

Publication series

NameCancer Treatment and Research
Volume153
ISSN (Print)0927-3042

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The menin gene'. Together they form a unique fingerprint.

  • Cite this

    Libutti, S. K., & Shen, H. C. J. (2010). The menin gene. In C. Sturgeon (Ed.), Endocrine Neoplasia (pp. 273-286). (Cancer Treatment and Research; Vol. 153). https://doi.org/10.1007/978-1-4419-0857-5_15