The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

D. Smotkin, F. O. Wettstein

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

In a previous study, the most abundant viral transcript in a human papillomavirus type 16-associated cervical cancer and in a cancer-derived cell line was characterized, and its translation product, the E7 protein, was identified (D. Smotkin and F.O. Wettstein, Proc. Natl. Acad. Sci. USA 68:4680-4684, 1986). Here we show that the E7 protein had a half life of about 1 h and was located in the soluble cytoplasmic fraction. The protein was phosphorylated at serine residues and exhibited a high heterogeneous sedimentation rate in nondenaturing glycerol gradients, suggesting an oligomer formation or association with cellular protein.

Original languageEnglish (US)
Pages (from-to)1686-1689
Number of pages4
JournalJournal of virology
Volume61
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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