The lymph proteome, peptidome, and degradome

Cristina C. Clement, Laura Santambrogio

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

During the last decade advanced proteomic analysis have allowed detailed characterization of the composition of the lymphatic fluid. A picture start to emerge indicating that far from being an ultra filtrate of the plasma the lymph carries a rich repertoire of proteins and peptides reflecting the tissue of origin and its physiological state. Indeed in few pathological conditions it has been shown that proteins transported by the lymph closely represent a molecular signature of the diseased organs. Altogether the omic analysis (proteomic, peptidomic, degradomic and lipidomic) prove to be a powerful tool to fingerprint variations in the lymph fluid collected from different parenchymal organs and to discover molecular biomarkers for the early detection of diseases.

Original languageEnglish (US)
Title of host publicationImmunology of the Lymphatic System
PublisherSpringer New York
Pages65-79
Number of pages15
Volume9781461432357
ISBN (Print)9781461432357, 1461432340, 9781461432340
DOIs
StatePublished - Dec 1 2013

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Clement, C. C., & Santambrogio, L. (2013). The lymph proteome, peptidome, and degradome. In Immunology of the Lymphatic System (Vol. 9781461432357, pp. 65-79). Springer New York. https://doi.org/10.1007/978-1-4614-3235-7_5