The lymph proteome, peptidome, and degradome

Cristina C. Clement; Laura Santambrogio

doi:10.1007/978-1-4614-3235-7_5

The lymph proteome, peptidome, and degradome

Cristina C. Clement, Laura Santambrogio

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

During the last decade advanced proteomic analysis have allowed detailed characterization of the composition of the lymphatic fluid. A picture start to emerge indicating that far from being an ultra filtrate of the plasma the lymph carries a rich repertoire of proteins and peptides reflecting the tissue of origin and its physiological state. Indeed in few pathological conditions it has been shown that proteins transported by the lymph closely represent a molecular signature of the diseased organs. Altogether the omic analysis (proteomic, peptidomic, degradomic and lipidomic) prove to be a powerful tool to fingerprint variations in the lymph fluid collected from different parenchymal organs and to discover molecular biomarkers for the early detection of diseases.

Original language	English (US)
Title of host publication	Immunology of the Lymphatic System
Publisher	Springer New York
Pages	65-79
Number of pages	15
Volume	9781461432357
ISBN (Electronic)	9781461432357
ISBN (Print)	1461432340, 9781461432340
DOIs	https://doi.org/10.1007/978-1-4614-3235-7_5
State	Published - Dec 1 2013

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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AB - During the last decade advanced proteomic analysis have allowed detailed characterization of the composition of the lymphatic fluid. A picture start to emerge indicating that far from being an ultra filtrate of the plasma the lymph carries a rich repertoire of proteins and peptides reflecting the tissue of origin and its physiological state. Indeed in few pathological conditions it has been shown that proteins transported by the lymph closely represent a molecular signature of the diseased organs. Altogether the omic analysis (proteomic, peptidomic, degradomic and lipidomic) prove to be a powerful tool to fingerprint variations in the lymph fluid collected from different parenchymal organs and to discover molecular biomarkers for the early detection of diseases.

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The lymph proteome, peptidome, and degradome

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