TY - JOUR
T1 - The lymph as a pool of self-antigens
AU - Clement, Cristina C.
AU - Rotzschke, Olaf
AU - Santambrogio, Laura
PY - 2011/1
Y1 - 2011/1
N2 - Prenodal lymph is generated from the interstitial fluid that surrounds organs, and thus contains products of organ metabolism and catabolism. New proteomic analyses of lymph have identified proteins and peptides that are derived from capillary extravasation and tissue-specific proteins. Many of these peptides are detected at nanomolar concentrations in the lymph before passage through a regional lymph node. Before entering the node and once inside, proteins and processed peptides are filtered from the lymph by circulating immature dendritic cells (DCs) or non-activated nodal antigen-presenting cells (APCs) (macrophages, B cells and immature DCs). Here, we suggest that this process ensures organ-specific self-antigens are displayed to circulating and nodal APCs, thus contributing to the maintenance of peripheral tolerance.
AB - Prenodal lymph is generated from the interstitial fluid that surrounds organs, and thus contains products of organ metabolism and catabolism. New proteomic analyses of lymph have identified proteins and peptides that are derived from capillary extravasation and tissue-specific proteins. Many of these peptides are detected at nanomolar concentrations in the lymph before passage through a regional lymph node. Before entering the node and once inside, proteins and processed peptides are filtered from the lymph by circulating immature dendritic cells (DCs) or non-activated nodal antigen-presenting cells (APCs) (macrophages, B cells and immature DCs). Here, we suggest that this process ensures organ-specific self-antigens are displayed to circulating and nodal APCs, thus contributing to the maintenance of peripheral tolerance.
UR - http://www.scopus.com/inward/record.url?scp=78650719866&partnerID=8YFLogxK
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U2 - 10.1016/j.it.2010.10.004
DO - 10.1016/j.it.2010.10.004
M3 - Short survey
C2 - 21123113
AN - SCOPUS:78650719866
SN - 1471-4906
VL - 32
SP - 6
EP - 11
JO - Trends in Immunology
JF - Trends in Immunology
IS - 1
ER -