The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans

Giuseppe Cassata, Hiroshi Kagoshima, Yoshiki Andachi, Yuji Kohara, Markus B. Dürrenberger, David H. Hall, Thomas R. Bürglin

Research output: Contribution to journalArticle

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Abstract

In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons, ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes, ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotacfic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.

Original languageEnglish (US)
Pages (from-to)587-597
Number of pages11
JournalNeuron
Volume25
Issue number3
StatePublished - 2000

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Homeobox Genes
Caenorhabditis elegans
Neurons
Interneurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cassata, G., Kagoshima, H., Andachi, Y., Kohara, Y., Dürrenberger, M. B., Hall, D. H., & Bürglin, T. R. (2000). The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. Neuron, 25(3), 587-597.

The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. / Cassata, Giuseppe; Kagoshima, Hiroshi; Andachi, Yoshiki; Kohara, Yuji; Dürrenberger, Markus B.; Hall, David H.; Bürglin, Thomas R.

In: Neuron, Vol. 25, No. 3, 2000, p. 587-597.

Research output: Contribution to journalArticle

Cassata, G, Kagoshima, H, Andachi, Y, Kohara, Y, Dürrenberger, MB, Hall, DH & Bürglin, TR 2000, 'The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans', Neuron, vol. 25, no. 3, pp. 587-597.
Cassata G, Kagoshima H, Andachi Y, Kohara Y, Dürrenberger MB, Hall DH et al. The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. Neuron. 2000;25(3):587-597.
Cassata, Giuseppe ; Kagoshima, Hiroshi ; Andachi, Yoshiki ; Kohara, Yuji ; Dürrenberger, Markus B. ; Hall, David H. ; Bürglin, Thomas R. / The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. In: Neuron. 2000 ; Vol. 25, No. 3. pp. 587-597.
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