The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans

Giuseppe Cassata, Hiroshi Kagoshima, Yoshiki Andachi, Yuji Kohara, Markus B. Dürrenberger, David H. Hall, Thomas R. Bürglin

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons, ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes, ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotacfic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.

Original languageEnglish (US)
Pages (from-to)587-597
Number of pages11
JournalNeuron
Volume25
Issue number3
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans'. Together they form a unique fingerprint.

  • Cite this

    Cassata, G., Kagoshima, H., Andachi, Y., Kohara, Y., Dürrenberger, M. B., Hall, D. H., & Bürglin, T. R. (2000). The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. Neuron, 25(3), 587-597. https://doi.org/10.1016/S0896-6273(00)81062-4