The lack of validity of predictive equations for calculating resting energy expenditure in asian indian patients with type 1 and type 2 diabetes mellitus

Riddhi Dasgupta, Padmanaban Venkatesan, Akankasha Goyal, Anneka Wickramanayake, K. Chaithanya Murthy, Mercy Inbakumari, Meredith A. Hawkins, Nihal Thomas

Research output: Contribution to journalArticle

Abstract

Introduction: Predictive equations are used routinely to calculate resting energy expenditure and administer appropriate nutrition to patients. Validity of routinely used equations for calculating resting energy expenditure was not verified in Asian Indian population. In this study we aim to compare the predictive equations with indirectly calorimetry to test their validity in Indian population. Methods: The study included 45 male Indian subjects divided into following groups: 16 patients with Type 1 diabetes mellitus, 13 patients with Type 2 Diabetes mellitus and 16 normoglycemic subjects. All underwent anthropometric measurements, body composition measurement by DEXA scan and indirect calorimetry. REE calculated from routinely used equations and a body composition based equation was compared with REE measured by indirect calorimetry by means of Bland-Altman plot analysis. Total and mean error was also calculated for the predictive equations. Statistical analysis was done in R programming language version 3.2.4. Results: Total error of different predictive equations when compared with indirect calorimetry ranged from 375 kcal/day to 726 kcal/day across the studied groups. Bland-Altman plot analysis showed negative proportional bias i.e. equations overestimate at lower values and underestimate at higher values of measured REE. Conclusion: Routinely used predictive equations and recently introduced body composition based equation were all poor in accuracy as reflected from their high total error for estimating resting energy expenditure in Indian population when compared with indirect calorimetry. We conclude that a predictive equation for estimating resting energy expenditure must be established for use in Indian population.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalIndian Journal of Physiology and Pharmacology
Volume62
Issue number3
StatePublished - Jul 1 2018

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Indirect Calorimetry
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Energy Metabolism
Body Composition
Population
Programming Languages
Calorimetry
Photon Absorptiometry

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Dasgupta, R., Venkatesan, P., Goyal, A., Wickramanayake, A., Chaithanya Murthy, K., Inbakumari, M., ... Thomas, N. (2018). The lack of validity of predictive equations for calculating resting energy expenditure in asian indian patients with type 1 and type 2 diabetes mellitus. Indian Journal of Physiology and Pharmacology, 62(3), 314-319.

The lack of validity of predictive equations for calculating resting energy expenditure in asian indian patients with type 1 and type 2 diabetes mellitus. / Dasgupta, Riddhi; Venkatesan, Padmanaban; Goyal, Akankasha; Wickramanayake, Anneka; Chaithanya Murthy, K.; Inbakumari, Mercy; Hawkins, Meredith A.; Thomas, Nihal.

In: Indian Journal of Physiology and Pharmacology, Vol. 62, No. 3, 01.07.2018, p. 314-319.

Research output: Contribution to journalArticle

Dasgupta, R, Venkatesan, P, Goyal, A, Wickramanayake, A, Chaithanya Murthy, K, Inbakumari, M, Hawkins, MA & Thomas, N 2018, 'The lack of validity of predictive equations for calculating resting energy expenditure in asian indian patients with type 1 and type 2 diabetes mellitus', Indian Journal of Physiology and Pharmacology, vol. 62, no. 3, pp. 314-319.
Dasgupta, Riddhi ; Venkatesan, Padmanaban ; Goyal, Akankasha ; Wickramanayake, Anneka ; Chaithanya Murthy, K. ; Inbakumari, Mercy ; Hawkins, Meredith A. ; Thomas, Nihal. / The lack of validity of predictive equations for calculating resting energy expenditure in asian indian patients with type 1 and type 2 diabetes mellitus. In: Indian Journal of Physiology and Pharmacology. 2018 ; Vol. 62, No. 3. pp. 314-319.
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