The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method

Chull S. Song, Irwin R. Merkatz, Arleen B. Rifkind, Peter N. Gillette, Attallah Kappas

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The concentrations of 11 plasma proteins were determined in 25 women in the third trimester of pregnancy, 31 women who had taken oral contraceptive agents containing synthetic estrogens and progestins for 3 months or longer, and 31 women of comparable ages who served as controls. Sera from fasting subjects were used to determine, by means of quantitative immunodiffusion assay, the level of each individual protein. Pregnancy and treatment with oral contraceptives produced increased mean serum levels of the following proteins: ceruloplasmin, α1-antitrypsin, transferrin, and β1A-globulin. The following proteins were decreased in concentration: α1-acid glycoprotein, haptoglobin, and albumin. The slight decrease in the mean concentration of serum albumin produced by oral contraceptives was not statistically significant. The concentrations of γA-globulin, γM-globulin, and α2-macroglobulin were not significantly altered by pregnancy or by treatment with oral contraceptives. γG-globulin was significantly reduced in pregnant woman. The effects of oral contraceptives on the concentrations of plasma proteins, although less marked, generally paralleled those produced by late pregnancy. The most striking alterations were noted in serum proteins that are known to be synthesized by the liver, an observation consistent with the significant influences which sex hormones exert on various metabolic activities of this organ.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume108
Issue number2
StatePublished - Sep 15 1970
Externally publishedYes

Fingerprint

Immunodiffusion
Oral Contraceptives
Globulins
Blood Proteins
Steroids
Pregnancy
Progesterone Congeners
Estradiol Congeners
Macroglobulins
Proteins
Ceruloplasmin
Haptoglobins
Third Pregnancy Trimester
Gonadal Steroid Hormones
Transferrin
Contraceptive Agents
Serum
Serum Albumin
Pregnant Women
Albumins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method. / Song, Chull S.; Merkatz, Irwin R.; Rifkind, Arleen B.; Gillette, Peter N.; Kappas, Attallah.

In: American Journal of Obstetrics and Gynecology, Vol. 108, No. 2, 15.09.1970, p. 227-231.

Research output: Contribution to journalArticle

@article{d1b9b73c006c4e10a1211fbe5278804e,
title = "The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method",
abstract = "The concentrations of 11 plasma proteins were determined in 25 women in the third trimester of pregnancy, 31 women who had taken oral contraceptive agents containing synthetic estrogens and progestins for 3 months or longer, and 31 women of comparable ages who served as controls. Sera from fasting subjects were used to determine, by means of quantitative immunodiffusion assay, the level of each individual protein. Pregnancy and treatment with oral contraceptives produced increased mean serum levels of the following proteins: ceruloplasmin, α1-antitrypsin, transferrin, and β1A-globulin. The following proteins were decreased in concentration: α1-acid glycoprotein, haptoglobin, and albumin. The slight decrease in the mean concentration of serum albumin produced by oral contraceptives was not statistically significant. The concentrations of γA-globulin, γM-globulin, and α2-macroglobulin were not significantly altered by pregnancy or by treatment with oral contraceptives. γG-globulin was significantly reduced in pregnant woman. The effects of oral contraceptives on the concentrations of plasma proteins, although less marked, generally paralleled those produced by late pregnancy. The most striking alterations were noted in serum proteins that are known to be synthesized by the liver, an observation consistent with the significant influences which sex hormones exert on various metabolic activities of this organ.",
author = "Song, {Chull S.} and Merkatz, {Irwin R.} and Rifkind, {Arleen B.} and Gillette, {Peter N.} and Attallah Kappas",
year = "1970",
month = "9",
day = "15",
language = "English (US)",
volume = "108",
pages = "227--231",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method

AU - Song, Chull S.

AU - Merkatz, Irwin R.

AU - Rifkind, Arleen B.

AU - Gillette, Peter N.

AU - Kappas, Attallah

PY - 1970/9/15

Y1 - 1970/9/15

N2 - The concentrations of 11 plasma proteins were determined in 25 women in the third trimester of pregnancy, 31 women who had taken oral contraceptive agents containing synthetic estrogens and progestins for 3 months or longer, and 31 women of comparable ages who served as controls. Sera from fasting subjects were used to determine, by means of quantitative immunodiffusion assay, the level of each individual protein. Pregnancy and treatment with oral contraceptives produced increased mean serum levels of the following proteins: ceruloplasmin, α1-antitrypsin, transferrin, and β1A-globulin. The following proteins were decreased in concentration: α1-acid glycoprotein, haptoglobin, and albumin. The slight decrease in the mean concentration of serum albumin produced by oral contraceptives was not statistically significant. The concentrations of γA-globulin, γM-globulin, and α2-macroglobulin were not significantly altered by pregnancy or by treatment with oral contraceptives. γG-globulin was significantly reduced in pregnant woman. The effects of oral contraceptives on the concentrations of plasma proteins, although less marked, generally paralleled those produced by late pregnancy. The most striking alterations were noted in serum proteins that are known to be synthesized by the liver, an observation consistent with the significant influences which sex hormones exert on various metabolic activities of this organ.

AB - The concentrations of 11 plasma proteins were determined in 25 women in the third trimester of pregnancy, 31 women who had taken oral contraceptive agents containing synthetic estrogens and progestins for 3 months or longer, and 31 women of comparable ages who served as controls. Sera from fasting subjects were used to determine, by means of quantitative immunodiffusion assay, the level of each individual protein. Pregnancy and treatment with oral contraceptives produced increased mean serum levels of the following proteins: ceruloplasmin, α1-antitrypsin, transferrin, and β1A-globulin. The following proteins were decreased in concentration: α1-acid glycoprotein, haptoglobin, and albumin. The slight decrease in the mean concentration of serum albumin produced by oral contraceptives was not statistically significant. The concentrations of γA-globulin, γM-globulin, and α2-macroglobulin were not significantly altered by pregnancy or by treatment with oral contraceptives. γG-globulin was significantly reduced in pregnant woman. The effects of oral contraceptives on the concentrations of plasma proteins, although less marked, generally paralleled those produced by late pregnancy. The most striking alterations were noted in serum proteins that are known to be synthesized by the liver, an observation consistent with the significant influences which sex hormones exert on various metabolic activities of this organ.

UR - http://www.scopus.com/inward/record.url?scp=0014949323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014949323&partnerID=8YFLogxK

M3 - Article

C2 - 5006482

AN - SCOPUS:0014949323

VL - 108

SP - 227

EP - 231

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -