The importance of biopsy sampling practices in the pathologic evaluation of gastrointestinal disorders

Nicole C. Panarelli, Rhonda K. Yantiss

Research output: Contribution to journalReview article

Abstract

Purpose of review To summarize the literature regarding appropriate endoscopic sampling and surveillance protocols for common inflammatory diseases of the digestive tract. Gastroenterologists increasingly use endoscopy with mucosal biopsy to detect inflammatory diseases, assess response to therapy, and monitor for progression to dysplasia. Recent findings Many diseases show a patchy distribution in the digestive tract and there may be poor correlation between the endoscopic appearance and presence of histologic abnormalities. Indeed, a clinician's ability to render a diagnosis is limited by endoscopic mucosal sampling. The appropriate number of tissue samples and required biopsy sites are not established for many gastrointestinal disorders, and adherence to guidelines may not yield a reliable diagnosis in all cases. Summary We discuss the evidence supporting current recommendations and emerging endoscopic techniques for the evaluation of eosinophilic esophagitis, Barrett esophagus, chronic gastritis, celiac disease, and inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)374-381
Number of pages8
JournalCurrent Opinion in Gastroenterology
Volume32
Issue number5
DOIs
StatePublished - Sep 1 2016

Fingerprint

Biopsy
Gastrointestinal Tract
Eosinophilic Esophagitis
Guideline Adherence
Barrett Esophagus
Celiac Disease
Gastritis
Inflammatory Bowel Diseases
Endoscopy
Therapeutics
Gastroenterologists

Keywords

  • diagnosis
  • distribution
  • endoscopy
  • number
  • site

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The importance of biopsy sampling practices in the pathologic evaluation of gastrointestinal disorders. / Panarelli, Nicole C.; Yantiss, Rhonda K.

In: Current Opinion in Gastroenterology, Vol. 32, No. 5, 01.09.2016, p. 374-381.

Research output: Contribution to journalReview article

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