@article{bfe795a35a6242f1a1eadbb9e747b347,
title = "The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures",
abstract = "Seizures are the most common neurological emergency in the neonatal period and in contrast to those in infancy and childhood, are often provoked seizures with an acute cause and may be electrographic-only. Hence, neonatal seizures may not fit easily into classification schemes for seizures and epilepsies primarily developed for older children and adults. A Neonatal Seizures Task Force was established by the International League Against Epilepsy (ILAE) to develop a modification of the 2017 ILAE Classification of Seizures and Epilepsies, relevant to neonates. The neonatal classification framework emphasizes the role of electroencephalography (EEG) in the diagnosis of seizures in the neonate and includes a classification of seizure types relevant to this age group. The seizure type is determined by the predominant clinical feature. Many neonatal seizures are electrographic-only with no evident clinical features; therefore, these are included in the proposed classification. Clinical events without an EEG correlate are not included. Because seizures in the neonatal period have been shown to have a focal onset, a division into focal and generalized is unnecessary. Seizures can have a motor (automatisms, clonic, epileptic spasms, myoclonic, tonic), non-motor (autonomic, behavior arrest), or sequential presentation. The classification allows the user to choose the level of detail when classifying seizures in this age group.",
keywords = "EEG, classification, epilepsy, neonatal seizures, semiology",
author = "Pressler, {Ronit M.} and Cilio, {Maria Roberta} and Mizrahi, {Eli M.} and Mosh{\'e}, {Solomon L.} and Nunes, {Magda L.} and Perrine Plouin and Sampsa Vanhatalo and Elissa Yozawitz and {de Vries}, {Linda S.} and {Puthenveettil Vinayan}, Kollencheri and Triki, {Chahnez C.} and Wilmshurst, {Jo M.} and Hitoshi Yamamoto and Zuberi, {Sameer M.}",
note = "Funding Information: Special thanks are given to all members of the ILAE and other stakeholders who have contributed to the public comments; their contribution to finalizing this classification was invaluable. Additional helpful key comments were received from the International Federation of Clinical Neurophysiology (an ad hoc group led by Dr Monika Eisermann, Paris). Funding Information: Ronit M. Pressler has no conflicts of interest in regards to this article. She is an investigator for studies with UCB and Johnson & Johnson. She served as a Consultant and on Advisory Boards for Esai and UCB. Her research is supported by the National Institute of Health Research (NIHR) Biomedical Research Centre at Great Ormond Street Hospital, Cambridge Biomedical Research Centre, NIHR and GOSH Charity. Solomon L. Mosh{\'e} has no conflicts of interest in regards to this article. He is the Charles Frost Chair in Neurosurgery and Neurology and partially funded by grants from National Institutes of Health (NIH) U54 NS100064 and NS43209, US Department of Defense (W81XWH‐13‐1‐0180 and EP170020), CURE Infantile Spasms Initiative, and the Heffer Family and the Segal Family Foundations and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/Dan Levitz families. He is serving as Associate Editor of and is on the editorial board of . He receives from Elsevier an annual compensation for his work as Associate Editor of and royalties from two books he co‐edited. He received a consultant fee from Eisai, Mallinckrodt, Pfizer, and UCB. Eli M. Mizrahi has no conflicts of interest with regard to this article. He has received consultant fees from Eisai and royalties from Elsevier, McGraw‐Hill and Springer publishers. Sameer M. Zuberi has no conflicts of interest in relation to this article. He has received research funding from Epilepsy Research UK, UCB Pharma, Dravet Syndrome UK, and Glasgow Childrens Hospital Charity. He has served as a Consultant and on Advisory Boards for Encoded Genomics, Zogenix, UCB Pharma, Biocodex. He receives an honorarium from Elsevier for his role as Editor‐in‐Chief of the . Jo M. Wilmshurst has no conflicts of interest in regard to this article. She has received a stipend from Wiley for her role as an Associate Editor for . Magda L. Nunes has no conflicts of interest in regards to this article. She is a researcher 1D supported by CNPq–Brazil, PQ grant number 306338/2017‐3. Sampsa Vanhatalo has no conflicts of interest in regards to this article. He is supported by the Finnish Academy (SV: 313242, 288220, 3104450), Pediatric foundation, and HUS Children{\textquoteright}s Hospital. Maria Roberta Cilio has no conflict of interest in regards to this article. She served as Consultant and on Advisory Boards for GW Pharmaceuticals, UCB, Sanofi Pharma, and Biocodex. She receives royalties from Elsevier as co‐editor of a book. The other authors have no conflict of interest to disclose in relation to this publication. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Neurobiology of Disease Brain and Development, Pediatric Neurology and Physiological Research Neurobiology of Disease European Journal of Paediatric Neurology Epilepsia Publisher Copyright: {\textcopyright} 2021 International League Against Epilepsy",
year = "2021",
month = mar,
doi = "10.1111/epi.16815",
language = "English (US)",
volume = "62",
pages = "615--628",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "3",
}