The hematopoietic stem cell niche

From embryo to adult

Xin Gao, Chunliang Xu, Noboru Asada, Paul S. Frenette

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.

Original languageEnglish (US)
Article numberdev139691
JournalDevelopment (Cambridge)
Volume145
Issue number2
DOIs
StatePublished - Jan 15 2018

Fingerprint

Stem Cell Niche
Hematopoietic Stem Cells
Embryonic Structures
Bone Marrow
Mesonephros
Regenerative Medicine
Gonads
Embryonic Development
Aorta
Maintenance
Liver

Keywords

  • Bone marrow
  • Hematopoietic stem cell
  • Hemogenic endothelium
  • Microenvironment
  • Niche

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

The hematopoietic stem cell niche : From embryo to adult. / Gao, Xin; Xu, Chunliang; Asada, Noboru; Frenette, Paul S.

In: Development (Cambridge), Vol. 145, No. 2, dev139691, 15.01.2018.

Research output: Contribution to journalReview article

Gao, Xin ; Xu, Chunliang ; Asada, Noboru ; Frenette, Paul S. / The hematopoietic stem cell niche : From embryo to adult. In: Development (Cambridge). 2018 ; Vol. 145, No. 2.
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