The fusogen EFF-I controls sculpting of mechanosensory dendrites

Meital Oren-Suissa, David H. Hall, Millet Treinin, Gidi Shemer, Benjamin Podbilewicz

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The mechanisms controlling the formation and maintenance of neuronal trees are poorly understood. We examined the dynamic development of two arborized mechanoreceptor neurons (PVDs) required for reception of strong mechanical stimuli in Caenorhabditis elegans. The PVDs elaborated dendritic trees comprising structural units we call "menorahs." We studied how the number, structure, and function of menorahs were maintained. EFF-1, an essential protein mediating cell fusion, acted autonomously in the PVDs to trim developing menorahs. eff-1 mutants displayed hyperbranched, disorganized menorahs. Overexpression of EFF-1 in the PVD reduced branching. Neuronal pruning appeared to involve EFF-1dependent branch retraction and neurite-neurite autofusion. Thus, EFF-1 activities may act as a quality control mechanism during the sculpting of dendritic trees.

Original languageEnglish (US)
Pages (from-to)1285-1288
Number of pages4
JournalScience
Volume328
Issue number5983
DOIs
StatePublished - Jun 4 2010

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Neurites
Dendrites
Mechanoreceptors
Neuronal Plasticity
Cell Fusion
Caenorhabditis elegans
Quality Control
Maintenance
Neurons
Proteins

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Oren-Suissa, M., Hall, D. H., Treinin, M., Shemer, G., & Podbilewicz, B. (2010). The fusogen EFF-I controls sculpting of mechanosensory dendrites. Science, 328(5983), 1285-1288. https://doi.org/10.1126/science.1189095

The fusogen EFF-I controls sculpting of mechanosensory dendrites. / Oren-Suissa, Meital; Hall, David H.; Treinin, Millet; Shemer, Gidi; Podbilewicz, Benjamin.

In: Science, Vol. 328, No. 5983, 04.06.2010, p. 1285-1288.

Research output: Contribution to journalArticle

Oren-Suissa, M, Hall, DH, Treinin, M, Shemer, G & Podbilewicz, B 2010, 'The fusogen EFF-I controls sculpting of mechanosensory dendrites', Science, vol. 328, no. 5983, pp. 1285-1288. https://doi.org/10.1126/science.1189095
Oren-Suissa M, Hall DH, Treinin M, Shemer G, Podbilewicz B. The fusogen EFF-I controls sculpting of mechanosensory dendrites. Science. 2010 Jun 4;328(5983):1285-1288. https://doi.org/10.1126/science.1189095
Oren-Suissa, Meital ; Hall, David H. ; Treinin, Millet ; Shemer, Gidi ; Podbilewicz, Benjamin. / The fusogen EFF-I controls sculpting of mechanosensory dendrites. In: Science. 2010 ; Vol. 328, No. 5983. pp. 1285-1288.
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