The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: The Myc connection

Julie Secombe, Robert N. Eisenman

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Epigenetic regulation of transcription refers to reversible, heritable changes in gene expression that occur in the absence of changes in DNA sequence. A major epigenetic mechanism involves the covalent modification of nucleosomal histones to create binding sites for transcriptional regulators and chromatin remodeling complexes that mediate activation or repression of transcription. While it has been known for a number of years that many histone modifications are reversible, it has only recently been shown that methyl groups are enzymatically removed from lysine residues. Here we discuss the recent characterization of a new class of demethylase enzyme, the JARID1 family, which catalyzes the removal of methyl groups from lysine 4 of histone H3. We summarize recent findings regarding the function of this family of proteins, focusing on our characterization of Little imaginal discs (Lid), the sole JARID1 family protein in Drosophila, which is rate-limiting for Myc-induced cell growth. Finally, we propose models to explain the role of Lid in Myc-mediated growth and discuss the relevance of these findings to human disease and tumor formation.

Original languageEnglish (US)
Pages (from-to)1324-1328
Number of pages5
JournalCell Cycle
Volume6
Issue number11
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Keywords

  • Demethylase
  • JARID1
  • Jumonji (Jmj)
  • Little imaginal discs (Lid)
  • Myc

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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