The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

The Extracellular RNA Communication Consortium

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.

Original languageEnglish (US)
Pages (from-to)231-242
Number of pages12
JournalCell
Volume177
Issue number2
DOIs
StatePublished - Apr 4 2019

Fingerprint

RNA
Technology
Communication
Research
Biomarkers
Research Personnel
Extracellular Vesicles
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The Extracellular RNA Communication Consortium : Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. / The Extracellular RNA Communication Consortium.

In: Cell, Vol. 177, No. 2, 04.04.2019, p. 231-242.

Research output: Contribution to journalReview article

The Extracellular RNA Communication Consortium. / The Extracellular RNA Communication Consortium : Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. In: Cell. 2019 ; Vol. 177, No. 2. pp. 231-242.
@article{a0af083180b647c1ba3b42e7c093c686,
title = "The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research",
abstract = "The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.",
author = "{The Extracellular RNA Communication Consortium} and Saumya Das and Abdel-Mageed, {Asim B.} and Catherine Adamidi and Adelson, {P. David} and Akat, {Kemal M.} and Eric Alsop and Ansel, {K. Mark} and Jorge Arango and Neil Aronin and Avsaroglu, {Seda Kilinc} and Azadeh Azizian and Leonora Balaj and Ben-Dov, {Iddo Z.} and Karl Bertram and Markus Bitzer and Robert Blelloch and Bogardus, {Kimberly A.} and Breakefield, {Xandra Owens} and Calin, {George A.} and Carter, {Bob S.} and Al Charest and Chen, {Clark C.} and Tanuja Chitnis and Coffey, {Robert J.} and Amanda Courtright-Lim and Amrita Datta and Peter DeHoff and Diacovo, {Thomas G.} and Erle, {David J.} and Alton Etheridge and Marc Ferrer and Franklin, {Jeffrey L.} and Freedman, {Jane E.} and Galas, {David J.} and Timur Galeev and Roopali Gandhi and Aitor Garcia and Gerstein, {Mark Bender} and Vikas Ghai and Ghiran, {Ionita Calin} and Giraldez, {Maria D.} and Andrei Goga and Tasos Gogakos and Beatrice Goilav and Gould, {Stephen J.} and Peixuan Guo and Mihir Gupta and Fred Hochberg and Bo Huang and Chaim Putterman",
year = "2019",
month = "4",
day = "4",
doi = "10.1016/j.cell.2019.03.023",
language = "English (US)",
volume = "177",
pages = "231--242",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - The Extracellular RNA Communication Consortium

T2 - Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

AU - The Extracellular RNA Communication Consortium

AU - Das, Saumya

AU - Abdel-Mageed, Asim B.

AU - Adamidi, Catherine

AU - Adelson, P. David

AU - Akat, Kemal M.

AU - Alsop, Eric

AU - Ansel, K. Mark

AU - Arango, Jorge

AU - Aronin, Neil

AU - Avsaroglu, Seda Kilinc

AU - Azizian, Azadeh

AU - Balaj, Leonora

AU - Ben-Dov, Iddo Z.

AU - Bertram, Karl

AU - Bitzer, Markus

AU - Blelloch, Robert

AU - Bogardus, Kimberly A.

AU - Breakefield, Xandra Owens

AU - Calin, George A.

AU - Carter, Bob S.

AU - Charest, Al

AU - Chen, Clark C.

AU - Chitnis, Tanuja

AU - Coffey, Robert J.

AU - Courtright-Lim, Amanda

AU - Datta, Amrita

AU - DeHoff, Peter

AU - Diacovo, Thomas G.

AU - Erle, David J.

AU - Etheridge, Alton

AU - Ferrer, Marc

AU - Franklin, Jeffrey L.

AU - Freedman, Jane E.

AU - Galas, David J.

AU - Galeev, Timur

AU - Gandhi, Roopali

AU - Garcia, Aitor

AU - Gerstein, Mark Bender

AU - Ghai, Vikas

AU - Ghiran, Ionita Calin

AU - Giraldez, Maria D.

AU - Goga, Andrei

AU - Gogakos, Tasos

AU - Goilav, Beatrice

AU - Gould, Stephen J.

AU - Guo, Peixuan

AU - Gupta, Mihir

AU - Hochberg, Fred

AU - Huang, Bo

AU - Putterman, Chaim

PY - 2019/4/4

Y1 - 2019/4/4

N2 - The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.

AB - The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=85063395528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063395528&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.03.023

DO - 10.1016/j.cell.2019.03.023

M3 - Review article

C2 - 30951667

AN - SCOPUS:85063395528

VL - 177

SP - 231

EP - 242

JO - Cell

JF - Cell

SN - 0092-8674

IS - 2

ER -