The efficacy and cost of aprotinin in children undergoing reoperative open heart surgery

Celia C. D'Errico, Jay R. Shayevitz, Sarah J. Martindale, Ralph S. Mosca, Edward L. Bove

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

We performed a prospective, randomized, placebo-controlled, double- blind trial to assess the efficacy of aprotinin in 61 children (median age 3.7 yr) undergoing reoperative open heart surgery (OHS). Three demographically similar groups were studied: large-dose aprotinin (ALD), small-dose aprotinin (ASD), and placebo (P). Over the first 24 postoperative hours fewer patients in the aprotinin groups received packed red cells (ALD, 53%; ASD, 89%; and P, 95%; P = 0.001), platelets (ALD, 32%; ASD, 50%; and P, 65%; P = 0.04), and fresh frozen plasma (ALD, 16%; ASD, 17%; and P, 60%; P = 0.003) than placebo patients. Most importantly, aprotinin patients had fewer exposures to banked blood components (ALD, median 1 U; and ASD, median 2 U) than P (median 6 U; P = 0.001), with no difference in overall complication rate. Use of aprotinin was associated with a savings in the patient charges for blood components, operating room time, and duration of hospitalization. In conclusion, aprotinin decreased the number of units of banked blood components used during the first 24 postoperative hours in reoperative pediatric OHS. Aprotinin thus decreases the risks associated with exposure to banked blood components and reduces hospital charges.

Original languageEnglish (US)
Pages (from-to)1193-1199
Number of pages7
JournalAnesthesia and analgesia
Volume83
Issue number6
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    D'Errico, C. C., Shayevitz, J. R., Martindale, S. J., Mosca, R. S., & Bove, E. L. (1996). The efficacy and cost of aprotinin in children undergoing reoperative open heart surgery. Anesthesia and analgesia, 83(6), 1193-1199. https://doi.org/10.1097/00000539-199612000-00011