The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: A pilot study

Vijaya L. Soma, Xuan Qin, Chuan Zhou, Amanda Adler, Jessica E. Berry, Danielle M. Zerr

Research output: Contribution to journalArticle

5 Scopus citations


Chlorhexidine gluconate (CHG) is a topical antiseptic used in a myriad of clinical settings. Recently, CHG baths have been shown to decrease multidrug-resistant organism acquisition and infections and catheter-associated bloodstream infections. The present study examined the effects of daily bathing with CHG on the recovery and antimicrobial susceptibility of cultivable cutaneous bacteria. The objectives of this study were to (1) explore the effects of clinical CHG bathing on cultivable cutaneous bacteria, (2) study the relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility of coagulase-negative staphylococci, and (3) demonstrate the feasibility of the approach so a more definitive study may be performed. Significant decreases in bacterial colony counts and phenotypic diversity occurred with greater CHG exposure. The findings also suggest an inverse relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility. Larger prospective studies are necessary to fully investigate the clinical impact of CHG usage.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalInfection and Drug Resistance
Issue number1
Publication statusPublished - May 28 2012
Externally publishedYes



  • Antiseptic
  • Coagulase-negative
  • Resistance
  • Staphylococcus

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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