The effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction

Steven Ira Berk, Peter Gal, Jerry L. Bauman, Jean B. Douglas, Jack D. McCue, J. Robert Powell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this study, we prospectively evaluated the effect of oral cimetidine on serum lidocaine concentrations in 6 patients with suspected myocardial infraction. Compared to baseline lidocaine levels, total lidocaine concentrations increased by 8.2 ± 7.8% at 6 hours, 16.4 ± 9.0% at 12 hours and 27.9 ± 9.4% at 24 hours after two doses of oral cimetidine. Unbound lidocaine concentrations increased by 14.3 ± 4.1% at 6 hours, and 18.3 ± 10.3% at 24 hours after cimetidine. In patients with myocardial infraction (3), total lidocaine concentrations increased by 24.2 ± 10.4%, whereas unbound lidocaine increased by 8.9 ± 10.2% at 24 hours. Therefore, increases in total lidocaine concentrations after cimetidine administration were considerably less than those previously reported and empiric dosage reductions of lidocaine in patients receiving cimetidine may not be appropriate.

Original languageEnglish (US)
Pages (from-to)91-94
Number of pages4
JournalInternational Journal of Cardiology
Volume14
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

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Cimetidine
Lidocaine
Myocardial Infarction
Serum

Keywords

  • Cimetidine
  • Drug interaction
  • Lidocaine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction. / Berk, Steven Ira; Gal, Peter; Bauman, Jerry L.; Douglas, Jean B.; McCue, Jack D.; Powell, J. Robert.

In: International Journal of Cardiology, Vol. 14, No. 1, 1987, p. 91-94.

Research output: Contribution to journalArticle

Berk, Steven Ira ; Gal, Peter ; Bauman, Jerry L. ; Douglas, Jean B. ; McCue, Jack D. ; Powell, J. Robert. / The effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction. In: International Journal of Cardiology. 1987 ; Vol. 14, No. 1. pp. 91-94.
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