The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

Jiali Wang; Rong Liu; Li Sen Liu; Rahena Chowdhury; Nir Barzilai; Jianzhen Tan; Luciano Rossetti

doi:10.1038/11335

The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

Jiali Wang, Rong Liu, Li Sen Liu, Rahena Chowdhury, Nir Barzilai, Jianzhen Tan, Luciano Rossetti

Medicine

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression in skeletal muscle, a tissue that normally does not express this gene. Changes in nutrient availability resulted in rapid alterations in Lep autoregulation. These findings demonstrate negative feedback regulation of Lep in fat, and indicate that leptin secretion can function as a vehicle of 'cross-talk' between adipose tissue and skeletal muscle, leading to tissue-specific modulation of the 'leptin signal'.

Original language	English (US)
Pages (from-to)	895-899
Number of pages	5
Journal	Nature Medicine
Volume	5
Issue number	8
DOIs	https://doi.org/10.1038/11335
State	Published - Aug 1999

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "The effect of leptin on Lep expression is tissue-specific and nutritionally regulated",

abstract = "Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression in skeletal muscle, a tissue that normally does not express this gene. Changes in nutrient availability resulted in rapid alterations in Lep autoregulation. These findings demonstrate negative feedback regulation of Lep in fat, and indicate that leptin secretion can function as a vehicle of 'cross-talk' between adipose tissue and skeletal muscle, leading to tissue-specific modulation of the 'leptin signal'.",

author = "Jiali Wang and Rong Liu and Liu, {Li Sen} and Rahena Chowdhury and Nir Barzilai and Jianzhen Tan and Luciano Rossetti",

note = "Funding Information: Acknowledgment This work was supported by grants to L.R. from the National Institutes of Health (DK 48321 and DK 45024) and the American Diabetes Association.",

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AU - Wang, Jiali

AU - Liu, Rong

AU - Liu, Li Sen

AU - Chowdhury, Rahena

AU - Barzilai, Nir

AU - Tan, Jianzhen

AU - Rossetti, Luciano

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N2 - Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression in skeletal muscle, a tissue that normally does not express this gene. Changes in nutrient availability resulted in rapid alterations in Lep autoregulation. These findings demonstrate negative feedback regulation of Lep in fat, and indicate that leptin secretion can function as a vehicle of 'cross-talk' between adipose tissue and skeletal muscle, leading to tissue-specific modulation of the 'leptin signal'.

AB - Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression in skeletal muscle, a tissue that normally does not express this gene. Changes in nutrient availability resulted in rapid alterations in Lep autoregulation. These findings demonstrate negative feedback regulation of Lep in fat, and indicate that leptin secretion can function as a vehicle of 'cross-talk' between adipose tissue and skeletal muscle, leading to tissue-specific modulation of the 'leptin signal'.

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The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

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