The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

Jiali Wang, Rong Liu, Li Sen Liu, Rahena Chowdhury, Nir Barzilai, Jianzhen Tan, Luciano Rossetti

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Leptin, the product of the Obese (Lep) gene, orchestrates behavioral and metabolic responses to nutrient intake. Here, we demonstrate tissue-specific autoregulation of Lep. Moderate increases in circulating leptin considerably decreased Lep expression in adipose tissue and induced lep expression in skeletal muscle, a tissue that normally does not express this gene. Changes in nutrient availability resulted in rapid alterations in Lep autoregulation. These findings demonstrate negative feedback regulation of Lep in fat, and indicate that leptin secretion can function as a vehicle of 'cross-talk' between adipose tissue and skeletal muscle, leading to tissue-specific modulation of the 'leptin signal'.

Original languageEnglish (US)
Pages (from-to)895-899
Number of pages5
JournalNature Medicine
Volume5
Issue number8
DOIs
StatePublished - Aug 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Wang, J., Liu, R., Liu, L. S., Chowdhury, R., Barzilai, N., Tan, J., & Rossetti, L. (1999). The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nature Medicine, 5(8), 895-899. https://doi.org/10.1038/11335